1202039-23-3

Basic information

• Product Name: (2R,2'R)-1-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]propan-2-ol
• Synonyms: (2R,2'R)-1-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]propan-2-ol
• CAS NO: 1202039-23-3
• Molecular Weight: 229.32
• Mol File: 1202039-23-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,2'R)-1-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,2'R)-1-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]propan-2-ol(1202039-23-3)
• EPA Substance Registry System: (2R,2'R)-1-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]propan-2-ol(1202039-23-3)

Safety Data

• Hazardous Substances Data: 1202039-23-3(Hazardous Substances Data)

Upstream product

• 86953-79-9 tert-butyl pyrrolidine-1-carboxylate 
• 15448-47-2 (R)-propylene oxide 

Downstream Products

• 496-47-9 (+)-hygroline 
• 154887-98-6 (4R,6R)-conioidine A 

Relevant articles and documents

Total synthesis of hygrolines and pseudohygrolines

A concise two-step synthesis of all four diastereoisomeric hygrolines ((-)-hygroline (1), (+)-hygroline (2), (-)-pseudohygroline (3), (+)-pseudohygroline (4)) has been developed based on the (-)-sparteine (5)- or (+)-sparteine surrogate 11-mediated enantioselective lithiation of N-Boc pyrrolidine (6), followed by reaction of the chiral anion with (S)- or (R)-propylene oxide. Reduction of the resulting N-Boc amino alcohols furnished hygrolines and pseudohygrolines in 30% to 56% overall yields with dr's > 95:5.