496-47-9 Usage
Description
(2R)-1-[(2R)-1-methylpyrrolidin-2-yl]propan-2-ol, also known as (R,R)-Methylphenidate, is a chiral tertiary alcohol with two chiral centers. It is the active ingredient in the medication Ritalin, which is commonly prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
Used in Pharmaceutical Industry:
(2R)-1-[(2R)-1-methylpyrrolidin-2-yl]propan-2-ol is used as a central nervous system stimulant for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It increases the levels of dopamine and norepinephrine in the brain, which can improve focus, attention, and impulse control in individuals with ADHD.
Used in Off-Label Treatments:
(2R)-1-[(2R)-1-methylpyrrolidin-2-yl]propan-2-ol is sometimes used off-label for the treatment of depression and as a cognitive enhancer. However, it has the potential for abuse and can produce side effects such as insomnia, loss of appetite, and increased heart rate.
Check Digit Verification of cas no
The CAS Registry Mumber 496-47-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,9 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 496-47:
(5*4)+(4*9)+(3*6)+(2*4)+(1*7)=89
89 % 10 = 9
So 496-47-9 is a valid CAS Registry Number.
496-47-9Relevant articles and documents
An enantioselective synthesis of (+)-hygroline and (+)-pseudohygroline via Keck allylation and CBS reduction
Bhoite, Shubhangi P.,Kamble, Rohit B.,Suryavanshi, Gurunath M.
, p. 4704 - 4705 (2015/08/06)
Abstract An enantioselective synthesis of (+)-hygroline and (+)-pseudohygroline has been achieved in high optical purity (98% ee) from readily available 1,4-butanediol. The synthesis strategy employs a Keck allylation, CBS reduction, and Wacker oxidation.
New synthesis of all the four isomers of 2-(2-hydroxypropyl)pyrrolidines via iterative asymmetric dihydroxylation to cause enantiomeric enhancement
Takahata, Hiroki,Kubota, Minoru,Momose, Takefumi
, p. 2801 - 2810 (2007/10/03)
Both enantiomers of 2-(2-propenyl)pyrrolidine 7 (75-84% ee), prepared via the asymmetric dihydroxylation (AD) of terminal olefin 5, underwent the second AD to provide all of the four stereoisomeric 2-(2-hydroxypropyl)pyrrolidines 8 with enantiomeric enhan
