1202361-84-9

Basic information

• Product Name: (2S,4aR,10aR)-9-methoxy-2-(3-phenyl-pyrazol-1-ylmethyl)-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazine
• Synonyms: (2S,4aR,10aR)-9-methoxy-2-(3-phenyl-pyrazol-1-ylmethyl)-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazine
• CAS NO: 1202361-84-9
• Molecular Weight: 417.551
• Mol File: 1202361-84-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4aR,10aR)-9-methoxy-2-(3-phenyl-pyrazol-1-ylmethyl)-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4aR,10aR)-9-methoxy-2-(3-phenyl-pyrazol-1-ylmethyl)-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazine(1202361-84-9)
• EPA Substance Registry System: (2S,4aR,10aR)-9-methoxy-2-(3-phenyl-pyrazol-1-ylmethyl)-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazine(1202361-84-9)

Safety Data

• Hazardous Substances Data: 1202361-84-9(Hazardous Substances Data)

Upstream product

• 90-15-3 α-naphthol 
• 27673-48-9 5,8-dihydro-1-naphthol 
• 36230-47-4 1,4-dihydro-5-methoxynaphthalene 
• 103009-62-7 3-methoxy-1a,2,7,7a-tetrahydronaphtho[2,3-b]oxirene 
• 138053-06-2 trans-3-azido-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-ol 
• 1202362-55-7 (2R,3R)-(3-hydroxy-5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid tert-butyl ester 
• 1202362-62-6 toluene-4-sulfonic acid (2S,4aR,10aR)-9-methoxy-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naptho[2,3-b][1,4]oxazin-2-ylmethyl ester 
• 2458-26-6 3-phenylpyrazole 
• 1202362-66-0 (2R,3R)-3-amino-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-ol hydrochloride 
• 1202362-68-2 (2R,3R)-8-methoxy-3-propylamino-1,2,3,4-tetrahydro-naphthalen-2-ol 
• 1202362-61-5 ((2S,4aR,10aR)-9-methoxy-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazin-2-yl)-methanol 

Relevant articles and documents

Synthesis and SAR study of a novel series of dopamine receptor agonists

The synthesis of a novel series of dopamine receptor agonists are described as well as their in vitro potency and efficacy on dopamine D1 and D2 receptors. This series was designed from pergolide and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinolin-6-ol (PHBQ) and resulted in the synthesis of (2R,4aR,10aR)-2-methylsulfanylmethyl-4-propyl- 3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazin-9-ol (compound 27), which has a D1 and D2 receptor profile similar to that of the most recently approved drug for Parkinson's disease, rotigotine.