1202362-62-6

Basic information

• Product Name: toluene-4-sulfonic acid (2S,4aR,10aR)-9-methoxy-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naptho[2,3-b][1,4]oxazin-2-ylmethyl ester
• Synonyms: toluene-4-sulfonic acid (2S,4aR,10aR)-9-methoxy-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naptho[2,3-b][1,4]oxazin-2-ylmethyl ester
• CAS NO: 1202362-62-6
• Molecular Weight: 445.58
• Mol File: 1202362-62-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: toluene-4-sulfonic acid (2S,4aR,10aR)-9-methoxy-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naptho[2,3-b][1,4]oxazin-2-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: toluene-4-sulfonic acid (2S,4aR,10aR)-9-methoxy-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naptho[2,3-b][1,4]oxazin-2-ylmethyl ester(1202362-62-6)
• EPA Substance Registry System: toluene-4-sulfonic acid (2S,4aR,10aR)-9-methoxy-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naptho[2,3-b][1,4]oxazin-2-ylmethyl ester(1202362-62-6)

Safety Data

• Hazardous Substances Data: 1202362-62-6(Hazardous Substances Data)

Upstream product

• 1202362-58-0 ((2S,4aR,10aR)-4-benzyl-9-methoxy-3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazin-2-yl)-methanol 
• 1202362-57-9 (2R,3R)-3-benzylamino-8-methoxy-1,2,3,4-tetrahydro-naphthalen-2-ol 
• 1202362-60-4 ((2S,4aR,10aR)-9-methoxy-3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazin-2-yl)-methanol 
• 1202362-68-2 (2R,3R)-8-methoxy-3-propylamino-1,2,3,4-tetrahydro-naphthalen-2-ol 
• 1202362-66-0 (2R,3R)-3-amino-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-ol hydrochloride 
• 1202362-55-7 (2R,3R)-(3-hydroxy-5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid tert-butyl ester 
• 138053-06-2 trans-3-azido-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-ol 
• 103009-62-7 3-methoxy-1a,2,7,7a-tetrahydronaphtho[2,3-b]oxirene 
• 36230-47-4 1,4-dihydro-5-methoxynaphthalene 
• 27673-48-9 5,8-dihydro-1-naphthol 
• 90-15-3 α-naphthol 
• 1202362-61-5 ((2S,4aR,10aR)-9-methoxy-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazin-2-yl)-methanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1202361-84-9 (2S,4aR,10aR)-9-methoxy-2-(3-phenyl-pyrazol-1-ylmethyl)-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazine 

Relevant articles and documents

Synthesis and SAR study of a novel series of dopamine receptor agonists

The synthesis of a novel series of dopamine receptor agonists are described as well as their in vitro potency and efficacy on dopamine D1 and D2 receptors. This series was designed from pergolide and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinolin-6-ol (PHBQ) and resulted in the synthesis of (2R,4aR,10aR)-2-methylsulfanylmethyl-4-propyl- 3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazin-9-ol (compound 27), which has a D1 and D2 receptor profile similar to that of the most recently approved drug for Parkinson's disease, rotigotine.

NOVEL PHENOLIC AND CATECHOLIC AMINES AND PRODRUGS THEREOF

The present invention relates to novel phenolic and catecholic amines of Formula I, to processes for their preparation, pharmaceutical compositions containing them, to their use in therapy and to their use in radiolabeled form as PET- or SPECT ligands.