1204176-45-3

Basic information

• Product Name: Methyl (4-Methylpiperidin-3-yl)carbaMate
• Synonyms: Methyl (4-Methylpiperidin-3-yl)carbaMate;Tofacitinib Related Impurity 4
• CAS NO: 1204176-45-3
• Molecular Formula: C8H16N2O2
• Molecular Weight: 172.22484
• Mol File: 1204176-45-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl (4-Methylpiperidin-3-yl)carbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl (4-Methylpiperidin-3-yl)carbaMate(1204176-45-3)
• EPA Substance Registry System: Methyl (4-Methylpiperidin-3-yl)carbaMate(1204176-45-3)

Safety Data

• Hazardous Substances Data: 1204176-45-3(Hazardous Substances Data)

Upstream product

• 694495-63-1 O-methyl-N-(4-methylpyridin-3-yl)carbamate 
• 3430-27-1 3-amino-4-methylpyridine 

Downstream Products

• 1354621-59-2 cis-N-benzyl-3-methoxycarbonylamino-4-methylpiperidine 
• 1228879-37-5 cis-N-benzyl-3-methoxycarbonylamino-4-methylpiperidine bis(hydrochloride) 
• 1616833-40-9 1-triryI-N,4-dimethylpiperidin-3-amine 
• 1616761-04-6 (3S,4S)-1-trityl-N,4-dimethylpiperidin-3-amine di-p-toluyl-L-tartaric acid salt 
• 1616760-93-0 (3R,4R)-1-trityl-N,4-dimethylpiperidin-3-amine 
• 1616760-94-1 C₃₉H₃₈ClN₅O₂S 
• 1616760-95-2 C₂₀H₂₄ClN₅O₂S 
• 1616760-96-3 C₃₂H₃₂ClN₅ 
• 1616760-97-4 N-((3R,4R)-4-methyl-piperidin-3-yl)-N-methyl-2-chloro-7H-pyrrolo[2,3-D]pyrimidine-4-amine 
• 477600-74-1 tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate 
• 1259404-17-5 tasocitinib 
• 540737-29-9 Tofacitinib citrate 
• 540737-29-9 tofacitinib hemi-citrate 
• 1616760-91-8 methyl-(1-trityl-4-methylpiperidin-3-yl)carbamate 

Relevant articles and documents

Synthesis method of tofacitinib intermediate

The invention provides a synthesis method of a tofacitinib intermediate. According to synthesis of cis-(4-methylpiperidine-3-yl) methyl carbamate, (4-methylpiperidine-3-yl) methyl carbamate is taken as an initial raw material, samarium iodide is taken as a hydrogenation agent, and water is taken as a hydrogen source to generate the cis-(4-methylpiperidine-3-yl) methyl carbamate. The method provided by the invention has the advantages of few byproducts, simple operation, high product yield and purity, and small amount of three wastes, and has excellent economic and environmental benefits.

THE PRESENT INVENTION RELATES TO PROCESS FOR THE PREPARATION OF TOFACITINIB AND INTERMEDIATES THEREOF.

The present invention relates to process for the preparation of tofacitinib and intermediates thereof.

3-Amino-piperadine derivatives and methods of manufacture

This invention relates to 3-amino piperadine derivatives, their intermediates and methods of manufacture. As such, the present invention includes methods of making a compound of the formulas (Ia) and (Ib) wherein R1, R2, R3/sub