3430-27-1

Basic information

• Product Name: 3-Amino-4-methylpyridine
• Synonyms: 4-METHYLPYRIDIN-3-AMINE;4-METHYL-PYRIDIN-3-YLAMINE;4-METHYL-3-PYRIDINAMINE;3-AMINO-4-PICOLINE;3-AMINO-4-METHYLPYRIDINE;IFLAB-BB F1957-0029;3-AMINO-4-METHYLPYRIDINE 98%;3-Pyridinamine, 4-methyl-
• CAS NO: 3430-27-1
• Molecular Formula: C₆H₈N₂
• Molecular Weight: 108.14
• EINECS: -0
• Product Categories: VARIOUSAMINE;Pyridine;Heterocycles;Heterocyclic Compound;Pyridines, Pyrimidines, Purines and Pteredines;Amines;Pyridines;Pyridines derivates;Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides;Boronic Acid;C6;Heterocyclic Building Blocks;Pyridine Series;Aromatics
• Mol File: 3430-27-1.mol
• Article Data: 20

Chemical Properties

• Melting Point: 102-106°C
• Boiling Point: 254°C
• Flash Point: 254°C
• Appearance: /
• Density: 1.0275 (estimate)
• Vapor Pressure: 0.0116mmHg at 25°C
• Refractive Index: 1.5560 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform, Ethyl Acetate, Methanol
• PKA: 6.83±0.18(Predicted)
• Sensitive: Hygroscopic
• BRN: 107792
• CAS DataBase Reference: 3-Amino-4-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-4-methylpyridine(3430-27-1)
• EPA Substance Registry System: 3-Amino-4-methylpyridine(3430-27-1)

Safety Data

• Hazard Codes: T,Xn
• Statements: 23/24/25-36/37/38-41-37/38-22-20/21/22
• Safety Statements: 26-36/37/39-45-36
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 3430-27-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H8N2/c1-5-2-3-8-4-6(5)7/h2-4H,7H2,1H3

Upstream product

• 5832-44-0 3-nitro-4-methylpyridine 
• 23056-33-9 2-chloro-4-methyl-5-nitro-pyridine 
• 23056-39-5 2-chloro-3-nitro-4-methylpyridine 
• 52090-68-3 N-(4-methylpyridin-3-yl)acetamide 
• 141-52-6 sodium ethanolate 
• 55314-29-9 4-methylnicotinic acid ethyl ester 
• 6316-67-2 3-pyridinecarboxylic acid,4-methyl-hydrazide 
• 21901-41-7 2-hydroxy-4-methyl-5-nitropyridine 
• 21901-40-6 2-amino-5-nitro-4-picoline 
• 6635-86-5 2-amino-4-methyl-3-nitropyridine 
• 21901-18-8 2-hydroxy-4-methyl-3-nitropyridine 
• 7440-44-0 pyrographite 
• 7440-05-3 palladium 
• 695-34-1 2-Amino-4-methylpyridine 

Downstream Products

• 126325-50-6 3-amino-2-bromo-4-methylpyridine 
• 126354-83-4 3-amino-2,6-dibromo-4-methylpyridine 
• 399-88-2 3-fluoro-4-methylpyridine 
• 764717-59-1 2,8-dimethyl[1,5]naphthyridine 
• 627511-06-2 2-(3-furyl)-1H-pyrrolo[2,3-c]pyridine 
• 863301-94-4 2-furan-2-yl-1H-pyrrolo[2,3-c]pyridine 
• 113975-42-1 2-tert-butyl-1H-pyrrolo<2,3-c>pyridine 
• 2922-05-6 N-(4-methyl-[3]pyridyl)-benzamide 
• 2922-07-8 2-phenyl-1H-pyrrolo[2,3-c]pyridine 
• 627511-04-0 2-(4-trifluoromethylphenyl)-1H-pyrrolo[2,3-c]pyridine 
• 627511-05-1 2-(4-bromophenyl)-1H-pyrrolo[2,3-c]pyridine 
• 40068-81-3 2-naphthalen-2-yl-1H-pyrrolo[2,3-c]pyridine 
• 180253-66-1 3-(tert-butyloxycarbonylamino)-4-methyl-pyridine 
• 52090-68-3 N-(4-methylpyridin-3-yl)acetamide 

Relevant articles and documents

Preparation method of (S)-4- (C)-3-(S)-bromopyridine (bromopyridine) (by machine translation)

The method disclosed by the invention has, the beneficial, effects :(1) that 4 - the reaction conditions are mild, the treatment is easy 4 - the method is easy to, operate, the, treatment, is easy . and the method is, easy to, operate 4 - and easy to ;(2) operate 4 - pH, 4 . (by machine translation)

A 4 - methyl -3 - bromo pyridine preparation method

The invention belongs to the field of organic synthesis, in particular to a 4 - methyl - 3 - bromo pyridine method, comprises the following steps: (1) to 4 - methyl - 3 - nitro pyridine as raw materials, methanol as solvent, under the effects of catalyst hydrogenation reduction, filtered, the filtrate is concentrated, be 4 - methyl - 3 - aminopyridine; (2) the 4 - methyl - 3 - aminopyridine reacts with acid to form the salt cooling to - 10 °C - 0 °C, [...], [...] sodium nitrite aqueous solution, pH adjusting solution is dropped is alkaline, and then extracted, drying, concentration, a 4 - methyl - 3 - bromo pyridine. The beneficial effect of the invention is: mild reaction conditions, is easy to operate, after treatment is simple, and easy to enlarge production, is extremely suitable for industrial production; good catalytic effect, high yield; low prices of raw materials, the production cost is low.

Preparation method for nevirapine intermediate

The invention relates to a preparation method for an intermediate, i.e., 2-chloro-3-amino-4-methylpyridine, of an anti-AIDs drug nevirapine. The intermediate has a chemical structural formula I as described in the specification. The preparation method is characterized in that 4-methylpyridine is subjected to halogenation, ammonia substitution and chlorination so as to prepare 2-chloro-3-amino-4-methylpyridine. The preparation reactions are as shown in the specifications, wherein X is bromine or chlorine; a halogenation condition is Br2/AlCl3/95-105 DEG C, Br2/AlCl3/MBr/110 to 130 DEG C (wherein M is Li, Na or K), Br2/Fe/135-145 DEG C, Cl2/AlCl3, Br2/FeCl3 or Br2/SnCl4; an ammonia substitution condition is NH3(g)/CuSO4/CH3OH/170-190 DEG C, NH3(aq)/CuSO4/170-190 DEG C, or NaNH2; and a chlorination reaction condition is Cl2/AlCl3 or HCl/H2O2/30-50 DEG C.