52090-68-3

Basic information

• Product Name: 3-ACETAMIDO-4-PICOLINE
• Synonyms: 3-ACETAMIDO-4-PICOLINE;AcetaMide, N-(4-Methyl-3-pyridinyl)-
• CAS NO: 52090-68-3
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Mol File: 52090-68-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 314.4°C at 760 mmHg
• Flash Point: 143.9°C
• Appearance: /
• Density: 1.137g/cm³
• Vapor Pressure: 0.000468mmHg at 25°C
• Refractive Index: 1.572
• PKA: 14.20±0.70(Predicted)
• CAS DataBase Reference: 3-ACETAMIDO-4-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ACETAMIDO-4-PICOLINE(52090-68-3)
• EPA Substance Registry System: 3-ACETAMIDO-4-PICOLINE(52090-68-3)

Safety Data

• Hazardous Substances Data: 52090-68-3(Hazardous Substances Data)

Usage

Description

3-ACETAMIDO-4-PICOLINE, also known as 3-Acetyl-4-methylpyridine, is an organic compound with the molecular formula C7H9N. It is a derivative of picoline, which is a type of heterocyclic compound with a nitrogen atom in the ring structure. 3-ACETAMIDO-4-PICOLINE is characterized by its unique chemical properties and potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
3-ACETAMIDO-4-PICOLINE is used as an intermediate in the synthesis of various pharmaceutical compounds. Its ability to form a wide range of derivatives makes it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Preparation of Phthalimide Derivatives:
3-ACETAMIDO-4-PICOLINE is used as a key component in the preparation of Phthalimide derivatives with JAK inhibitory activity. These derivatives have potential applications in the treatment of various diseases, including autoimmune disorders and cancer, by targeting the Janus kinase (JAK) signaling pathway, which plays a crucial role in cell proliferation and immune response.

InChI:InChI=1/C8H10N2O/c1-6-3-4-9-5-8(6)10-7(2)11/h3-5H,1-2H3,(H,10,11)

Upstream product

• 3430-27-1 3-amino-4-methylpyridine 
• 75-36-5 acetyl chloride 
• 5832-44-0 3-nitro-4-methylpyridine 
• 108-24-7 acetic anhydride 

Downstream Products

• 1124194-63-3 N-(4-formylpyridin-3-yl)acetamide 
• 1260214-14-9 N-[4-(2,3,5-tri-O-benzyl-1-hydroxy-α-D-ribofuranosylmethyl)pyridin-3-yl]acetamide 
• 1039738-27-6 1-benzyl-4-methyl-3-amino piperidine 
• 3430-27-1 3-amino-4-methylpyridine 

Relevant articles and documents

Isobenzazole-1-ketone compound having anti-inflammatory activity

The invention discloses an isobenzazole-1-ketone compound having an anti-inflammatory activity, and provides a compound shown in the formula (I) or a pharmaceutically acceptable salt of the compound.The disclosed isobenzazole-1-ketone compound having the anti-inflammatory activity obviously strengthens the drug targeting, and achieves better treatment effects on the diseases like multiple myelomaand rheumatoid arthritis.

AN IMPROVED PROCESS FOR THE PREPARATION OF (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE

The present invention is related to an improved and efficient process for preparation of (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine which comprises: (a) N-acylation of 3-Amino-4-methyl pyridine; (b) Quarternization of 3-Acetylamino-4- methyl pyridine using benzyl halide; (c) Partial reduction of quarternized 3-Acetylamino- 4-methyl pyridine by Sodium borohydride in Methanol or water; (d) Hydrolysis of partially reduced product to 1-Benzyl-4-methylpiperidin-3-one in presence of acid; (e) Reductive animation of 1-Benzyl-4-methylpiperidin-3-one using Methanolic methylamine in presence of Titanium(IV) isopropoxide in Methanol; (f) Resolution of 1-Benzyl-4- methylpiperidin-3-yl)-methylamine using Ditoluoyl (L) tartaric acid to get (3R,4R)-(1- benzyl-4-methylpiperidin-3-yl)-methylamine. The invention is also related to novel intermediates.

HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE

The present invention relates to compounds useful as modulators of TGR5 and methods for the treatment or prevention of metabolic, cardiovascular, and inflammatory diseases.