1039738-27-6

Basic information

• Product Name: 1-Benzyl-4-Methylpiperidin-3-aMine
• Synonyms: 1-Benzyl-4-Methylpiperidin-3-aMine;4-methyl-1-(phenylmethyl)-3-Piperidinamine
• CAS NO: 1039738-27-6
• Molecular Formula: C₁₃H₂₀N₂
• Molecular Weight: 204.311
• Mol File: 1039738-27-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Benzyl-4-Methylpiperidin-3-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-4-Methylpiperidin-3-aMine(1039738-27-6)
• EPA Substance Registry System: 1-Benzyl-4-Methylpiperidin-3-aMine(1039738-27-6)

Safety Data

• Hazardous Substances Data: 1039738-27-6(Hazardous Substances Data)

Usage

General Description

1-Benzyl-4-methylpiperidin-3-amine is a chemical compound that belongs to the class of substituted piperidines. It has a molecular formula of C15H22N2 and a molecular weight of 234.35 g/mol. 1-Benzyl-4-Methylpiperidin-3-aMine is commonly used as an intermediate in the synthesis of pharmaceuticals and organic chemicals. Its structure consists of a piperidine ring with a benzyl and methyl group attached to it, as well as an amine group. It is important to handle this compound with care and follow proper safety guidelines, as it can be hazardous if not used properly.

Upstream product

• 100-39-0 benzyl bromide 
• 52090-68-3 N-(4-methylpyridin-3-yl)acetamide 
• 3430-27-1 3-amino-4-methylpyridine 
• 1206875-41-3 cis-(1-Benzyl-4-methyl-piperidin-3-yl)-carbamic Acid Methyl Ester 

Downstream Products

• 1228879-37-5 N,4-dimethyl-1-(phenylmethyl)-3-piperidineamine bishydrochloride 
• 1354621-59-2 trans-(1-benzyl-4-methylpiperidin-3-yl)methylamine 
• 1259404-17-5 3-(trans-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 
• 923036-25-3 N-(trans-1-benzyl-4-methylpiperidin-3-yl)-2-chloro-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 384338-23-2 (1-benzyl-4-methyl-piperidin-3-yl)-methyl-amine 
• 1263420-08-1 4-(1-benzyl-4-methylpiperidin-3-ylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide 
• 1263420-07-0 4-(1-benzyl-4-methylpiperidin-3-ylamino)pyrrolo[1,2-b]pyridazine-3-carbonitrile 

Relevant articles and documents

Synthesis method of tofacitinib citrate diastereomer impurities

The invention discloses a synthesis method of tofacitinib citrate diastereomer impurities, relates to the technical field of drug organic synthesis, and relates to 3 - amino -4 - methylpyridine as a starting material and a quaternary ammonium salt. Raw materials of the whole synthetic route are easily available, the reaction conditions are mild, the post-treatment separation and purification operation is simple and feasible, and the preparation method is good in repeatability.

Preparation method of tofacitinib intermediate

The invention discloses a preparation method of a tofacitinib intermediate compound-1-benzyl-3-methyl amino-4-methyl piperidine dihydrochloride. The method comprises the following steps: (1) carrying out selective deprotection on a compound as shown in a structural formula (V) to synthesize a compound-1-benzyl-3-amino-4-methyl piperidine as shown in a structural formula (VI); (2) enabling the compound as shown in the structural formula (VI) to have a primary amine monomethylation reaction to generate the target compound-1-benzyl-3-methyl amino-4-methyl piperidine dihydrochloride as shown in a structural formula (I). The method has the characteristics of being easy in obtaining of raw materials, novel in route, less in by-products, simple and convenient to operate, high in yield, and the like.