21901-18-8

Basic information

• Product Name: 2-Hydroxy-4-methyl-3-nitropyridine
• Synonyms: 4-METHYL-3-NITRO-2-PYRIDINOL;4-METHYL-3-NITRO-2-PYRIDONE;4-METHYL-3-NITROPYRIDIN-2-OL;2(1H)-PYRIDINONE, 4-METHYL-3-NITRO-;2-HYDROXY-3-NITRO-4-METHYLPYRIDINE;2-HYDROXY-3-NITRO-4-PICOLINE;2-HYDROXY-4-METHYL-3-NITROPYRIDINE;Hydroxymethylnitropyridine
• CAS NO: 21901-18-8
• Molecular Formula: C₆H₆N₂O₃
• Molecular Weight: 154.12
• Product Categories: Pyridine;Pyridines;Building Blocks;C6;Chemical Synthesis;Heterocyclic Building Blocks;Heterocycle-Pyridine series
• Mol File: 21901-18-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 229-232 °C(lit.)
• Boiling Point: 277.46°C (rough estimate)
• Flash Point: 167 °C
• Appearance: Pale yellow/Crystalline Solid
• Density: 1.4564 (rough estimate)
• Vapor Pressure: 0.000639mmHg at 25°C
• Refractive Index: 1.5100 (estimate)
• Solubility: soluble in Dimethylformamide
• PKA: 8.40±0.10(Predicted)
• BRN: 139125
• CAS DataBase Reference: 2-Hydroxy-4-methyl-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-4-methyl-3-nitropyridine(21901-18-8)
• EPA Substance Registry System: 2-Hydroxy-4-methyl-3-nitropyridine(21901-18-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• Hazardous Substances Data: 21901-18-8(Hazardous Substances Data)

Usage

Description

2-Hydroxy-4-methyl-3-nitropyridine is a yellow crystalline powder with a unique chemical structure that has been studied for its conformational stability and vibrational analysis. It is a useful research chemical with potential applications in various fields.

Uses

Used in Research and Development:
2-Hydroxy-4-methyl-3-nitropyridine is used as a research chemical for the study of its conformational stability and vibrational analysis. This helps in understanding its chemical properties and potential applications in different industries.
Used in Pharmaceutical Industry:
2-Hydroxy-4-methyl-3-nitropyridine is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure makes it a valuable building block for the development of new drugs.
Used in Chemical Industry:
2-Hydroxy-4-methyl-3-nitropyridine is used as a starting material for the production of various chemical compounds. Its versatility in chemical reactions allows for the creation of a wide range of products.
Used in Material Science:
2-Hydroxy-4-methyl-3-nitropyridine is used in the development of new materials with specific properties. Its unique structure and chemical properties can contribute to the creation of advanced materials for various applications.

InChI:InChI=1/C6H6N2O3/c1-4-2-3-7-6(9)5(4)8(10)11/h2-3,5H,1H3/t5-/m1/s1

Upstream product

• 6635-86-5 2-amino-4-methyl-3-nitropyridine 
• 695-34-1 2-Amino-4-methylpyridine 

Downstream Products

• 23056-39-5 2-chloro-3-nitro-4-methylpyridine 
• 21203-74-7 4-methyl-3-nitropyridine-2-carboxaldehyde 
• 399-88-2 3-fluoro-4-methylpyridine 
• 3430-27-1 3-amino-4-methylpyridine 
• 59290-82-3 3-nitropyridine-4-carboxylic acid 
• 393-53-3 3-fluoroisonicotinic acid 
• 343-72-6 ethyl 3-fluoroisonicotinate 
• 52334-77-7 3-benzoylamino-4-methyl-2-pyridone 
• 179524-47-1 4-(2-trimethylsiloxyphenethyl)-3-nitro-2-oxo-1,2-dihydro-1-pyridine 
• 353281-15-9 2-chloro-3-nitroisonicotinic acid 
• 1612242-37-1 4-[(S)-1-(4-chloro-3-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide 
• 1612242-38-2 4-[(S)-2-azetidin-1-yl-1-(3-chloro-4-trifluoromethoxy-phenyl)-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylamide 
• 1612242-58-6 C₂₄H₁₉F₄N₇O₅S 
• 1612242-74-6 C₂₅H₂₀ClF₃N₆O₆S 

Relevant articles and documents

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Novel Substituted Purine Isosteres: Synthesis, Structure-Activity Relationships and Cytotoxic Activity Evaluation

A number of pyrrolo[2,3-c]pyridines, pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines were designed and synthesized as antiproliferative agents. The target compounds possessed selected substituents in analogous positions on the central scaffold th

Simple preparation method of nevirapine

The invention relates to a simple preparation method of nevirapine. In the invention, 2-nitro-3-methyl-4-halo-5-oxo-n-valerate is obtained by 1,4-addition reaction of 2-nitroacetate and 2-halogenatedcrotonaldehyde, then 3-nitro-4-methylpyridine-2-one is obtained by cyclization with ammonia, and 2-chloro-3-nitro-4-methylpyridine is prepared by chlorination reagent. 2-cyclopropyl aminonicotinic acid is prepared from 2-chloronicotinic acid and cyclopropylamine through a first substitution reaction, 2-[N-cyclopropyl-N-(3-nitro-4-methylpyridine-2-yl)] aminonicotinic acid is prepared from 2-chloro-3-nitro-4-methylpyridine through a second substitution reaction, and nevirapine is prepared through catalytic hydrogenation and amidation reaction. The method has the advantages of cheap and easily available raw materials, mild process, simple and convenient operation, high reaction activity, high product yield and purity, and small amount of three wastes.

Synthesis and Antiproliferative Activity of New pyrazolo[3,4-c]pyridines

Background: Several pyrazolopyridines possess promising pharmacological activities, mainly attributed to their antagonistic nature towards the natural purines in many biological processes. Cytotoxicity and anticancer potential of this class of compounds a