1204698-94-1Relevant articles and documents
Cascade Reaction by Chemo- and Biocatalytic Approaches to Obtain Chiral Hydroxy Ketones and anti 1,3-Diols
Gandolfi, Raffaella,Facchetti, Giorgio,Christodoulou, Michael S.,Fusè, Marco,Meneghetti, Fiorella,Rimoldi, Isabella
, p. 393 - 400 (2018/06/04)
A chemo- and biocatalytic cascade approach was applied for the stereoselective synthesis of hydroxy ketones and the corresponding 1,3-diols. A new class of tridentate N,N,O ligands was used with copper(II) complexes for the asymmetric β-borylation of α,β-unsaturated compounds. The complex containing ligand L5 emerged as the best performer, and it gave the organoborane derivatives with good ee values. The corresponding keto–alcohol compounds were then bioreduced by yeasts. The biotransformation set up with Rhodotorula rubra allowed (R)-keto–alcohols and (S,S)-diols to be obtained with up to 99 % ee and up to 99 % de in favor of the anti enantiomers.
One-pot chemoenzymatic synthesis of chiral 1,3-diols using an enantioselective aldol reaction with chiral Zn2+ complex catalysts and enzymatic reduction using oxidoreductases with cofactor regeneration
Sonoike, Shotaro,Itakura, Toshinari,Kitamura, Masanori,Aoki, Shin
experimental part, p. 64 - 74 (2012/04/04)
We previously reported on enantioselective aldol reactions of acetone and some aldehydes catalyzed by chiral Zn2+ complexes of L-prolyl-pendant [12]aneN4 (L-ZnL1) and L-valyl-pendant [12]aneN 4 (L-ZnL2/sup
