120627-46-5

Basic information

• Product Name: N-benzyl-6-nitroindole
• Synonyms: N-benzyl-6-nitroindole
• CAS NO: 120627-46-5
• Molecular Weight: 252.272
• Mol File: 120627-46-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-benzyl-6-nitroindole(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-6-nitroindole(120627-46-5)
• EPA Substance Registry System: N-benzyl-6-nitroindole(120627-46-5)

Safety Data

• Hazardous Substances Data: 120627-46-5(Hazardous Substances Data)

Upstream product

• 19727-83-4 6-nitroindoline 
• 100-39-0 benzyl bromide 
• 4769-96-4 6-nitroindole 
• 100-44-7 benzyl chloride 
• 3377-71-7 N-benzylindole 

Downstream Products

• 915037-85-3 2-benzyl-6-nitro-1H-indole 
• 1416892-37-9 C₁₇H₁₆N₂O₂ 
• 1416892-36-8 C₁₇H₁₄N₂O₄ 
• 1416892-35-7 C₁₆H₁₂N₂O₄ 
• 934231-65-9 1-(1-benzyl-6-nitro-1H-indole-3-yl)-2,2,2-trifluoroethanone 
• 187668-94-6 1-benzyl-1H-indol-6-ylamine 
• 120627-60-3 1-Benzyl-6-nitro-7-(toluene-4-sulfonylmethyl)-1H-indole 

Relevant articles and documents

An Expeditious One-Pot Synthesis of N-Substituted 6-Nitroindoles from Indolines

This paper reports an one-pot method for the concomitant alkylation - oxidation (aromatization) of indolines, particularly effective to get easy access to N-alkyl-6-nitroindoles, which are useful platforms in medicinal chemistry. N-alkyl-6-nitroindoles are obtained in good yield (64-91%) by reaction at room temperature in non-degassed DMF of 6-nitroindoline, an alkyl halide, and NaH as base. The presence of NaH appears to be essential for a high yield conversion.

NOVEL FUSED PYRROLE DERIVATIVE

Disclosed is a compound represented by the formula (1) below which is useful as a glucocorticoid receptor function regulating agent, an anti-inflammatory drug or an antidiabetic drug, or a pharmaceutically acceptable salt thereof. (1) [In the formula, R1 represents an aralkyl group or the like; R2 represents a hydrogen atom or the like; -W4=W5-W6=W7- represents a group expressed as the following formula: -CR4=CR5-CR6=CR7- (wherein R4, R5, R6 and R7 independently represent a group expressed as the following formula: -E-A (wherein E represents a single bond and A represents a hydrogen atom, a nitro group or the like)) or the like; R8 represents a group expressed as the following formula: -OR11 (wherein R11 represents a hydrogen atom or the like) or the like; R9 represents a trifluoromethyl group or the like; and R10 represents a group expressed as the following formula: -[C(R13)R14]n-R15 (wherein R13 and R14 independently represent a hydrogen atom or the like, n represents an integer of 0-10, and R15 represents a group expressed as the following formula: -N(R18)R19 (wherein R18 and R19 represent a monocyclic nitrogen-containing heterocyclic ring or the like together with a nitrogen atom to which they are bonded) or the like).]

N-ARYLPHENYLACETAMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME

N-Arylphenylacetamide derivatives represented by the following formula [I]: (wherein R1 is C1-6 alkoxy, etc.; R2 is hydrogen, -(CH2)m-N(R6)(R7) (m is an integer of from 1 to 4; R