120739-77-7

Basic information

• Product Name: 2-chloro-5-ethylaminomethylpyridine
• Synonyms: N-Ethyl(6-chloro-3-pyridyl)methylamine;6-CHLORO-N-ETHYL-3-PYRIDINEMETHANAMINE;N-(6-Chloro-3-pyridylmethyl)-N-ethylamine;N-[(6-Chloropyridin-3-yl)methyl]ethanamine
• CAS NO: 120739-77-7
• Molecular Formula: C₈H₁₁ClN₂
• Molecular Weight: 170.64
• Mol File: 120739-77-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 254℃
• Flash Point: 108℃
• Appearance: /
• Density: 1.117
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-chloro-5-ethylaminomethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-ethylaminomethylpyridine(120739-77-7)
• EPA Substance Registry System: 2-chloro-5-ethylaminomethylpyridine(120739-77-7)

Safety Data

• Hazardous Substances Data: 120739-77-7(Hazardous Substances Data)

Usage

Uses

2-?Chloro-?5-?ethylamino Methyl Pyridine is an impurity of Nitenpyram (N490115), a chloronicotinyl insecticide; orally administered flea adulticide. Nitenpyram is used as an ectoparasiticide.

Upstream product

• 150824-47-8 nitenpiram 
• 70258-18-3 2-chloro-5-(chloromethyl)pyridine 
• 75-04-7 ethylamine 
• 69045-78-9 2-chloro-5-(Trichloromethyl)-pyridine 
• 72637-18-4 2-chloro-5-(dichloromethyl)-pyridine 

Downstream Products

• 150824-47-8 nitenpiram 
• 1355615-40-5 N-(phenmethoxycarbonylmethyl)-2-[4-[(6-chloro-3-pyridinylmethyl)ethylamino]-3-methyl-5-nitro-1-(1,2,3,6-tetrahydropyrimidinyl)]acetamide 
• 1234618-74-6 C₁₀H₁₁Cl₂N₃O₂ 
• 1233210-31-5 cis-2-amino-6-[N-(6-chloro-3-pyridinylmethyl)-N-ethyl]amino-3-cyano-1-methyl-5-nitro-4-(4-nitrophenyl)-1,4-dihydropyridine 
• 1394005-28-7 cis-2-amino-6-[N-(6-chloro-3-pyridinylmethyl)-N-ethyl]amino-3-methoxycarbonyl-1-methyl-5-nitro-4-(4-nitrophenyl)-1,4-dihydropyridine 
• 1309216-22-5 cis-2-amino-4-(4-chlorophenyl)-6-[N-(6-chloro-3-pyridinylmethyl)-N-ethyl]amino-3-cyano-1-methyl-5-nitro-1,4-dihydropyridine 
• 1309357-47-8 cis-2-amino-4-(2-chlorophenyl)-6-[N-(6-chloro-3-pyridinylmethyl)-N-ethyl]amino-3-ethoxycarbonyl-1-methyl-5-nitro-1,4-dihydropyridine 
• 1394005-26-5 cis-2-amino-4-(4-chlorophenyl)-6-[N-(6-chloro-3-pyridinylmethyl)-N-ethyl]amino-1-methyl-3-methoxycarbonyl-5-nitro-1,4-dihydropyridine 
• 1233210-00-8 cis-2-amino-6-[N-(6-chloro-3-pyridinylmethyl)-N-ethyl]amino-3-cyano-1-methyl-5-nitro-4-phenyl-1,4-dihydropyridine 
• 1309357-45-6 cis-2-amino-6-[N-(6-chloro-3-pyridinylmethyl)-N-ethyl]amino-3-ethoxycarbonyl-1-methyl-5-nitro-4-phenyl-1,4-dihydropyridine 
• 1394005-25-4 cis-2-amino-6-[N-(6-chloro-3-pyridinylmethyl)-N-ethyl]amino-1-methyl-3-methoxycarbonyl-4-phenyl-5-nitro-1,4-dihydropyridine 
• 1394005-33-4 cis-2-amino-6-[N-(6-chloro-3-pyridinylmethyl)-N-ethyl]amino-3-cyano-1-methyl-5-nitro-4-(4-triflourophenyl)-1,4-dihydropyridine 
• 1394005-32-3 cis-2-amino-6-[N-(6-chloro-3-pyridinylmethyl)-N-ethyl]amino-3-cyano-4-(4-isopropylphenyl)-1-methyl-5-nitro-1,4-dihydropyridine 
• 1309357-52-5 cis-2-amino-4-(4-chlorophenyl)-6-[N-(6-chloro-3-pyridinylmethyl)-N-ethyl]amino-3-methoxycarbonyl-1-methyl-5-nitro-1,4-dihydropyridine 

Relevant articles and documents

Synthesis, insecticidal activity, crystal structure, and molecular docking studies of nitenpyram analogues with an ω-hydroxyalkyl ester arm anchored on the tetrahydropyrimidine ring

On the basis of the research of the proposed modes of action between neonicotinoids and insect nicotinic acetylcholine receptor (nAChR), a new series of nitenpyram analogues with an ω-hydroxyalkyl ester arm anchored on the tetrahydropyrimidine ring was designed and synthesized to further enhance the strength of the hydrogen-bonding action they display in binding with the nAChR. The structures of the target compounds were characterized by 1H NMR, IR, and elemental analysis, and the cis configuration was confirmed by X-ray diffraction. Preliminary bioassays indicated that all of the nitenpyram analogues exhibited good insecticidal activity against Nilaparvata lugens and Myzus persicae at 100 mg/L, whereas analogues 4d and 6a afforded the best in vitro activity that had ≥95% mortality at 4 mg/L; the LC50 values of the analogues 4d and 6a were 0.170 and 0.154 mg/L, respectively. Structure-activity relationship (SAR) studies suggested that their insecticidal potency was also dual-controlled by the flexibility and size of the molecule. In addition, molecular docking simulations revealed that analogues 4d and 6a displayed stronger hydrogen-bonding action in binding with the nAChR, which explained the SARs observed in vitro and implied that the designed nitenpyram analogues are both practical and feasible.

Nitrogenous heterocyclic compound and use thereof

The invention relates to a nitrogenous heterocyclic compound with a novel structure and use thereof. The nitrogenous heterocyclic compound is a compound represented by a formula I (shown in the description) or a salt thereof acceptable in pesticide science. The nitrogenous heterocyclic compound provided by the invention can serve as a pesticide. Compared with the existing pesticides, the pesticide provided by the invention has the advantages that the chemical stability is better, and meanwhile, the killing activity to resistant insects is better.

Pyridine methylamino pyridine compound and method for preparing the same

The invention discloses a picolinate amino pyridine compound which is shown in the formula (I) and has sterilizing, insect/mite killing and weeding bioactivity as well as a preparation method thereof, a sterilizing, insect/mite killing and weeding herbicide composition containing the compound, and an application and method for controlling fungi, insects/mites and weeds by using the compound.