69045-78-9

Basic information

• Product Name: 2-Chloro-5-trichloromethylpyridine
• Synonyms: IFLAB-BB F0797-0001;2-CHLORO-5-TRICHLOROMETHYL PYRIDINE;AKOS BBS-00000412;69045-78-9;2-Chloro-5-trichloromethylpyridine###NA
• CAS NO: 69045-78-9
• Molecular Formula: C₆H₃Cl₄N
• Molecular Weight: 230.90672
• EINECS: 1308068-626-2
• Product Categories: Halides;Pyridines;Pyridine;API Intermediate;Heterocycle-Pyridine series;Imidazoles
• Mol File: 69045-78-9.mol
• Article Data: 21

Chemical Properties

• Melting Point: -18.14 °C
• Boiling Point: 281.8°C at 760 mmHg
• Flash Point: 151.2 °C
• Appearance: /
• Density: 1.582 g/cm³
• Vapor Pressure: 0.00596mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.26±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-5-trichloromethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-trichloromethylpyridine(69045-78-9)
• EPA Substance Registry System: 2-Chloro-5-trichloromethylpyridine(69045-78-9)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-25
• Safety Statements: 26-37/39-45
• RIDADR: UN2811
• Hazardous Substances Data: 69045-78-9(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-trichloromethylpyridine is a chemical compound with the molecular formula C6H3Cl4N. It is primarily used as a pesticide and herbicide due to its ability to control a wide range of pests and weeds. The compound is highly toxic and poses serious health risks to humans and animals if not handled and used with caution. Exposure to 2-Chloro-5-trichloromethylpyridine can result in skin and eye irritation, respiratory issues, and even more severe health problems if ingested or inhaled. Proper safety measures and protective equipment should be used when handling this chemical, and its use should be strictly regulated to minimize its potential harm to the environment and living organisms.

InChI:InChI=1/C6H3Cl4N/c7-5-2-1-4(3-11-5)6(8,9)10/h1-3H

Upstream product

• 3510-66-5 2-Bromo-5-methylpyridine 
• 70258-18-3 2-chloro-5-(chloromethyl)pyridine 
• 18368-64-4 2-chloro-5-methylpyridine 
• 108-99-6 3-Methylpyridine 
• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 59-67-6 nicotinic acid 
• 3099-50-1 3-trichloromethyl-pyridine 
• 52334-81-3 2-chloro-5-trifluoromethylpyridine 

Downstream Products

• 26218-80-4 6-methoxy-nicotinic acid methyl ester 
• 95652-81-6 6-chloro-2-methoxy-3-pyridinecarboxaldehyde 
• 120739-77-7 N-(6-chloro-pyridin-3-yl)methyl-N-ethylamine 
• 120739-62-0 1-(6-chloropyridin-3-yl)-N-methylmethanamine 
• 101990-44-7 N'-((6-chloropyridin-3-yl)methyl)ethane-1,2-diamine 
• 71701-93-4 2-chloro-5-chlorodifluoromethylpyridine 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 217096-52-1 NC₅H₃-6-Cl-3-CCo₃(CO)9 
• 217096-53-2 NC₅H₄-3-CCo₃(CO)9 
• 58584-80-8 2,3,6-trichloro-5-(trichloromethyl)pyridine 
• 69045-82-5 2-fluoro-5-(trifluoromethyl)pyridine 
• 70258-18-3 2-chloro-5-(chloromethyl)pyridine 
• 69045-84-7 2,3-dichloro-5-trifluoromethylpyridine 
• 69045-83-6 2,3-dichloro-5-(trichloromethyl)pyridine 

Relevant articles and documents

Synthesis, characterization and crystal structure of 2,3,6-trichloro-5- (trichloromethyl)pyridine

2,3,6-Trichloro-5-(trichloromethyl)pyridine (TCTCMP) was synthesized from 2-chloro-5-chloromethyl pyridine (CCMP) through two-steps chloridization using chlorine as chlorizating agent. Initially, 2-chloro-5-chloromethyl pyridine was chloridized for 8 h at reflux conditions in the presence of ultraviolet and transformed into 2-chloro-5-(trichloromethyl)pyridine (CTCMP), then CTCMP was chloridized for 6 h at 175 °C with WCl6 as catalyst. The product was characterized by FT-IR, NMR and elemental analysis. The crystal structure of TCTCMP was investigated using X-ray diffraction and SHELXTL97 software and the result indicated that TCTCMP crystallized in the orthorhombic system, space group Pbcm with a = 8.3100(17), b = 17.018 (3), c = 7.3160(15) A, V = 1034.6 (4) A3; Z 4.

2-chloro-5-trichloromethyl pyridine rectification purification method and device

The invention discloses a 2-chloro-5-trichloromethyl pyridine rectification purification method and device. Rectification purification of 2-chloro-5-trichloromethyl pyridine is implemented by using adevice for rectification purification of 2-chloro-5-trichloromethyl pyridine. By adopting the device for rectification purification of the 2-chloro-5-trichloromethyl pyridine, purification of a crudeproduct of 2-chloro-5-trichloromethyl pyridine can be efficiently implemented, the device is simple in structure and low in cost, and together with a purification method for the crude product of the 2-chloro-5-trichloromethyl pyridine, the purification rate of the crude product of the 2-chloro-5-trichloromethyl pyridine can be greatly increased.

Method for preparing 2, 3, 6-trichloropyridine

The invention discloses a preparation method of 2, 3, 6-trichloropyridine. The preparation method comprises the following steps: taking 3-methylpyridine and chlorine as raw materials and preparing 2,3, 6-trichloropyridine through catalytic one-step gas-phase chlorination and trichloromethyl removal by a molecular sieve catalyst in the presence of water vapor. The molecular sieve catalyst is prepared by taking raw molecular sieve powder as an active component. The raw material 3-methylpyridine adopted in the invention is a byproduct in the synthesis of pyridine by an aldehyde ammonia method, and the source is cheap and easy to obtain. The molecular sieve catalyst has strong treatment capacity, the 3-methylpyridine and the chlorine are used as the raw materials, a proper amount of water isadded, gas-phase chlorination and trichloromethyl removal reactions are carried out under the action of a molecular sieve acid center and water vapor molecules, and the 2, 3, 6-trichloropyridine is synthesized by one step. The process is simple, the product purity and conversion rate are high, the yield can be maintained at 85% or above generally, the maximum yield can reach up to 95%, and the preparation method of the 2, 3, 6-trichloropyridine has good industrial application prospect.