1208146-92-2

Basic information

• Product Name: C₂₃H₁₇Cl₂N₅O₂
• CAS NO: 1208146-92-2
• Molecular Weight: 466.326
• Mol File: 1208146-92-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₁₇Cl₂N₅O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₁₇Cl₂N₅O₂(1208146-92-2)
• EPA Substance Registry System: C₂₃H₁₇Cl₂N₅O₂(1208146-92-2)

Safety Data

• Hazardous Substances Data: 1208146-92-2(Hazardous Substances Data)

Upstream product

• 154016-48-5 (5-methyl-3-isoxazolyl)methylamine 
• 1034266-31-3 5-(4-chloro-phenyl)-1-(2-chloro-phenyl)-4-cyanomethyl-1H-pyrazole-3-carboxylic acid 

Relevant articles and documents

Exploring SAR features in diverse library of 4-cyanomethyl-pyrazole-3-carboxamides suitable for further elaborations as CB1 antagonists

A chemically diverse library of secondary and tertiary 4-cyanomethyl-1,5-diphenyl-1H-pyrazole-3-carboxamides was synthesized to enable mapping of the SAR, in the eastern amide region, with regard to CB1 antagonist activity, This study was initiated as a prelude to the design and synthesis of possible CB1 antagonists that do not readily pass the blood-brain-barrier. In general a range of modifications were found to be tolerated in this part of the molecule, although polar and especially charged groups did to a degree reduce the CB1 antagonistic activity. Several compounds with single-digit or even sub-nanomolar potency, suitable for further elaboration of the nitrile moiety, were identified.