154016-48-5

Basic information

• Product Name: (5-Methyl-3-isoxazolyl)methylamine
• Synonyms: 3-(Aminomethyl)-5-methylisoxazole;(5-Methyl-3-isoxazolyl)methylamine, 95+%;(5-methylisoxazol-3-yl)methanamine;(5-Methyl-3-isoxazolyl)methylamine ,97%;1-(5-methylisoxazol-3-yl)methanamine(SALTDATA: HBr);(5-Methylisoxazol-3-yl)methylamine, (5-Methyl-1,2-oxazol-3-yl)methylamine, 3-(Aminomethyl)-5-methyl-1,2-oxazole;(5-Methyl-1,2-oxazol-3-yl)MethanaMine;(5-Methyl-3-isoxazolyi)MethylaMine
• CAS NO: 154016-48-5
• Molecular Formula: C₅H₈N₂O
• Molecular Weight: 112.13
• Product Categories: Heterocycle;Oxazoles, Isoxazoles & Benzoxazoles;Aminomethyl's
• Mol File: 154016-48-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 54-56°C 0,7mm
• Flash Point: 87 °C
• Appearance: /
• Density: 1.102 g/cm³
• Vapor Pressure: 0.114mmHg at 25°C
• Refractive Index: 1.5
• CAS DataBase Reference: (5-Methyl-3-isoxazolyl)methylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (5-Methyl-3-isoxazolyl)methylamine(154016-48-5)
• EPA Substance Registry System: (5-Methyl-3-isoxazolyl)methylamine(154016-48-5)

Safety Data

• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 2735
• HazardClass: IRRITANT
• Hazardous Substances Data: 154016-48-5(Hazardous Substances Data)

Usage

General Description

(5-Methyl-3-isoxazolyl)methylamine, also known as MIMA, is a chemical compound that contains a methyl group attached to an isoxazole ring and a primary amine group. It has the molecular formula C5H8N2O and a molecular weight of 112.13 g/mol. MIMA is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and compounds, including medications for the treatment of various neurological disorders. It can also be used as a building block in the production of agrochemicals and other fine chemicals. MIMA is a clear, colorless to pale yellow liquid with a characteristic odor, and it should be handled and stored with proper safety precautions due to its potential hazards.

InChI:InChI=1/C5H8N2O/c1-4-2-5(3-6)7-8-4/h2H,3,6H2,1H3

Upstream product

• 3209-72-1 ethyl 5-methylisoxazole-3-carboxylate 
• 130628-75-0 3-(bromomethyl)-5-methylisoxazole 
• 109-80-8 1.3-propanedithiol 
• 154016-53-2 3-(azidomethyl)-5-methylisoxazole 
• 39499-34-8 5-methyl-3-isoxazolyl chloride 
• 3445-52-1 5-methyl-isoxazole-3-carbothioic acid amide 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 35166-33-7 (5-methyl-isoxazol-3-yl)-methanol 
• 57351-99-2 5-methyl-1,2-oxazole-3-carbonitrile 

Downstream Products

• 943002-46-8 tert-butyl N-[2-[[4-[3-methyl-5-[[(5-methyl-1,2-oxazol-3-yl)methylamino]methyl]pyridin-2-yl]benzoyl]amino]phenyl]carbamate 
• 1253299-02-3 N-[(5-methylisoxazol-3-yl)methyl]-2,4-diphenylthiazole-5-carboxamide 
• 1344700-34-0 3-({[N-(biphenyl-4-ylcarbonyl)-O-ethyl-N-methyl-3-oxoseryl]amino}methyl)-5-methyl-1,2-oxazole 
• 1344707-44-3 (R/S)-2-hydroxy-N-((5-methylisoxazol-3-yl)methyl)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide 
• 1251463-33-8 N-[(5-methyl-isoxazol-3-yl)methyl]-6-(2,2,2-trifluoroethoxy)-N'-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine 
• 1208146-92-2 C₂₃H₁₇Cl₂N₅O₂ 
• 1202927-42-1 2-(1-(3,4-difluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-((5-methylisoxazol-3-yl)methyl)isonicotinamide 
• 1219005-61-4 ethyl 2-((6-(4-fluorophenyl)pyridin-3-yl)methoxy)-2-methyl-3-(((5-methylisoxazol-3-yl)methyl)amino)-3-oxopropanoate 
• 1219005-58-9 methyl 2-(biphenyl-4-ylmethoxy)-2-methyl-3-(((5-methylisoxazol-3-yl)methyl)amino)-3-oxopropanoate 

Relevant articles and documents

Reactions of β-diketone compounds with nitriles catalyzed by Lewis acids: A simple approach to β-enaminone synthesis

Aluminium chloride selectively promoted the nucleophilic attack of β-diketone compounds with nitriles to give enaminones. Moreover a plausible mechanism for this transformation was given.

Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives

The present invention is a compound of formula wherein R1 is halogen or lower alkyl; R2 is hydrogen, lower alkyl, cycloalkyl, —(CH2)m-phenyl, wherein the phenyl ring may be substituted by lower alkoxy, or is —(CH2)m-indolyl; R3 is —C(O)O-lower alkyl, —C(O)OH, or a five membered heteroaromatic group, which rings may be substituted by lower alkyl or cycloalkyl; n is 0, 1 or 2; m is 0, 1 or 2; or a pharmaceutically acceptable acid addition salt thereof. Compound I shows high affinity and selectivity for GALA A α5 receptor binding sites.