121189-89-7

Basic information

• Product Name: 2-Propenoic acid, 2-methyl-3-(3,4,5-trimethoxyphenyl)-, (E)-
• CAS NO: 121189-89-7
• Molecular Formula: C13H16O5
• Molecular Weight: 252.267
• Mol File: 121189-89-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-methyl-3-(3,4,5-trimethoxyphenyl)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-methyl-3-(3,4,5-trimethoxyphenyl)-, (E)-(121189-89-7)
• EPA Substance Registry System: 2-Propenoic acid, 2-methyl-3-(3,4,5-trimethoxyphenyl)-, (E)-(121189-89-7)

Safety Data

• Hazardous Substances Data: 121189-89-7(Hazardous Substances Data)

Upstream product

• 516-05-2 methyl-propanedioic acid 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 157373-92-7 (+/-)-methyl 2-[hydroxy(3,4,5-trimethoxyphenyl)methyl]prop-2-enoate 
• 123-62-6 propionic acid anhydride 
• 138613-42-0 methyl (E)-2-methyl-3-(3,4,5-trimethoxyphenyl)propenoate 

Downstream Products

• 1542627-15-5 (E)-1-(2-methyl-3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one 
• 1571062-06-0 (E)-1-(2-methyl-3-(3,4,5-trimethoxyphenyl)acryloyl)-3-morpholino-5,6-dihydropyridine-2(1H)-one 
• 1571062-03-7 (E)-3-chloro-1-(2-methyl-3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridine-2(1H)-one 
• 1571062-22-0 (E)-3-bromo-1-(2-methyl-3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridine-2(1H)-one 
• 200188-57-4 C₁₃H₁₅ClO₄ 
• 16603-18-2 (3,4,5-trimethoxyphenyl)acetone 
• 138613-39-5 (2RS,3SR)-2,3-dimethyl-1,4-bis(3,4,5-trimethoxyphenyl)butan-1-one 
• 138613-39-5 (2RS,3RS)-2,3-dimethyl-1,4-bis(3,4,5-trimethoxyphenyl)butan-1-one 
• 72730-21-3 (2R,3S)-2,3-Dimethyl-1,4-bis-(3,4,5-trimethoxy-phenyl)-butan-1-ol 
• 72730-21-3 (2R,3R)-2,3-Dimethyl-1,4-bis-(3,4,5-trimethoxy-phenyl)-butan-1-ol 
• 138613-41-9 3-methyl-1,4-bis(3,4,5-trimethoxyphenyl)butan-1-one 
• 138613-45-3 2-methyl-3-(3,4,5-trimethoxyphenyl)propyl p-toluenosulfonate 
• 138613-43-1 methyl 2-methyl-3-(3,4,5-trimethoxyphenyl)propanoate 
• 138613-44-2 2-methyl-3-(3,4,5-trimethoxyphenyl)propan-1-ol 

Relevant articles and documents

CA amide analogs and its preparation method and application

The invention relates to the technical field of medicines. Piplartine is alkaloid extracted from perennial herbaceous vine piper longum of piperaceae. The invention provides a Piplartine analogue, which comprises a cis-trans-isomer, and any arbitrary mixture in those forms or medicinal salt thereof, and the structural formula of the Piplartine analogue is shown in a general formula (I). The invention also provides a preparation method of substituted Piplartine compounds, and an application thereof in preparation of an antitumor medicament.

Design, synthesis and biological activity of piperlongumine derivatives as selective anticancer agents

In an effort to expand the structure-activity relationship of the natural anticancer compound piperlongumine, we have prepared sixteen novel piperlongumine derivatives with halogen or morpholine substituents at C2 and alkyl substituents at C7. Most of 2-halogenated piperlongumines showed potent in vitro activity against four cancer cells and modest selectivity for lung normal cells. The highly active anticancer compound 11h exhibited obvious ROS elevation and excellent in vivo antitumor potency with suppressed tumor growth by 48.58% at the dose of 2 mg/kg. The results indicated that halogen substituents as electrophilic group at C2 played an important role in increasing cytotoxicity.

Intramolecular Oxidative Coupling of Aromatic Compounds. II. The Synthesis of (2RS,3SR)- and (2RS,3RS)-2,3-Dimethyl-1,4-bis(3,4,5-trimethoxyphenyl)butan-1-one and the Determination of Stereochemistry

The C-methylation of 3-methyl-1,4-bis(3,4,5-trimethoxyphenyl)butan-1-one (9) gave in a ratio of 4:1 the diastereoisomers, (2RS,3SR)- and (2RS,3RS)-2,3-dimethyl-1,4-bis(3,4,5-trimethoxyphenyl)butan-1-one, (7) and (8) respectively.The stereochemistry of eac