16603-18-2

Basic information

• Product Name: 3,4,5-TRIMETHOXYPHENYLACETONE
• Synonyms: 1-(3',4',5'-TRIMETHOXYPHENYL)-2-PROPANONE;3,4,5-TRIMETHOXYPHENYLACETONE;1-(3,4,5-TriMethoxyphenyl)propan-2-one;1-(3,4,5-Trimethoxyphenyl)acetone
• CAS NO: 16603-18-2
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 224.25
• Product Categories: Aromatic Ketones (substituted)
• Mol File: 16603-18-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 58-62°C
• Boiling Point: 314.9°Cat760mmHg
• Flash Point: 136.1°C
• Appearance: /
• Density: 1.078g/cm³
• Vapor Pressure: 0.000451mmHg at 25°C
• Refractive Index: 1.493
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3,4,5-TRIMETHOXYPHENYLACETONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-TRIMETHOXYPHENYLACETONE(16603-18-2)
• EPA Substance Registry System: 3,4,5-TRIMETHOXYPHENYLACETONE(16603-18-2)

Safety Data

• Hazardous Substances Data: 16603-18-2(Hazardous Substances Data)

Usage

General Description

3,4,5-Trimethoxyphenylacetone is a chemical compound with a molecular formula of C12H16O4. It is a phenylacetone derivative and is also known by the chemical name "Vanillin Acetate". 3,4,5-TRIMETHOXYPHENYLACETONE is a clear, colorless to yellowish liquid with a sweet, floral odor. It is commonly used as a flavoring agent in the food industry, particularly in the production of vanilla flavoring. Additionally, 3,4,5-trimethoxyphenylacetone has been studied for its potential antimicrobial and antioxidant properties. 3,4,5-TRIMETHOXYPHENYLACETONE is also used in the synthesis of various pharmaceuticals and other organic compounds.

InChI:InChI=1/C12H16O4/c1-8(13)5-9-6-10(14-2)12(16-4)11(7-9)15-3/h6-7H,5H2,1-4H3

Upstream product

• 200188-57-4 C₁₃H₁₅ClO₄ 
• 121189-89-7 (E)-2-methyl-3-(3,4,5-trimethoxyphenyl)propenoic acid 
• 38059-94-8 (E)-1,2,3-trimethoxy-5-(2-nitroprop-1-enyl)benzene 
• 67-64-1 acetone 
• 1207429-54-6 3,4,5-trimethoxyphenyl 1H-imidazole-1-sulfonate 
• 107951-78-0 1,2,3-Trimethoxy-5-[2-methylsulfanyl-2-(toluene-4-sulfonyl)-ethyl]-benzene 
• 107951-75-7 1,2,3-Trimethoxy-5-[(E)-2-methylsulfanyl-2-(toluene-4-sulfonyl)-vinyl]-benzene 
• 148123-60-8 1-(4-benzyloxy-3,5-dimethoxyphenyl)propan-2-one 
• 148123-59-5 3-(4-benzyloxy-3,5-dimethoxyphenyl)-2-methylpropene 
• 148123-58-4 2,6-dimethoxy-4-(2-methylprop-2-enyl)phenol 
• 148123-56-2 1,3-dimethoxy-2-(2-methylprop-2-enyloxy)benzene 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 91-10-1 1,3-dimethoxy-2-hydroxy-benzene 
• 19037-58-2 1-(3,5-dimethoxy-4-hydroxyphenyl)propan-2-one 

Downstream Products

• 126278-73-7 4-Morpholin-4-yl-3-(3,4,5-trimethoxy-phenyl)-butan-2-one; hydrochloride 
• 136178-78-4 2-(3,4,5-trimethoxybenzyl)-2,3-dimethyloxazolidine 
• 50544-08-6 5,5'-(2,3-dimethylbutane-1,4-diyl)bis(1,2,3-trimethoxybenzene) 
• 835922-48-0 (S)-1-(3,4,5-trimethoxyphenyl)-2-propanol 
• 835922-46-8 (R)-1-(3,4,5-trimethoxyphenyl)-2-propanol 

Relevant articles and documents

A convenient and efficient one-pot synthesis of arylacetones from (E)-3-aryl-2-methylacrylic acids by curtius rearrangement

A convenient and efficient method was developed for the synthesis of arylacetones from (E)-3-aryl-2-methylacrylic acids through a Curtius rearrangement. The Curtius rearrangement of (E)-3-aryl-2-methylacryloyl azides and subsequent hydrolysis proceeded at mild temperatures in a two-phase medium of carbon tetrachloride and water containing a catalytic amount of tetrabutylammonium bromide to give the corresponding derivatives in 82-93% yield.

Addressing challenges in palladium-catalyzed cross-couplings of aryl mesylates: Monoarylation of ketones and primary alkyl amines

Mor(DalPhos) for Me(sylates): Described are the first examples of ketone mono-α-arylation and primary aliphatic amine monoarylation employing aryl methanesulfonate coupling partners. A range of functionalized aryl mesylates were employed with dialkyl ketones, and also with primary and secondary amines as well as the otherwise challenging coupling partners acetone and methylamine. Ad=adamantyl. Copyright

Fe-HCl: An efficient reagent for deprotection of oximes as well as selective oxidative hydrolysis of nitroalkenes and nitroalkanes to ketones

Fe-HCl mixture was found to selectively perform oxidative hydrolysis of the nitroalkenes 1a-j and nitroalkanes 2a-j to the ketones 3a-j. Also, the reagent was observed to deprotect the oximes 7a-j to carbonyl compounds 8a-j in excellent yields.