1215279-81-4

Basic information

• Product Name: (1aS,6aR)-3,5-dichloro-6,6a-di-hydro-1aH-1-oxa-cyclopropa[a]indene
• Synonyms: (1aS,6aR)-3,5-dichloro-6,6a-di-hydro-1aH-1-oxa-cyclopropa[a]indene
• CAS NO: 1215279-81-4
• Molecular Weight: 201.052
• Mol File: 1215279-81-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (1aS,6aR)-3,5-dichloro-6,6a-di-hydro-1aH-1-oxa-cyclopropa[a]indene(CAS DataBase Reference)
• NIST Chemistry Reference: (1aS,6aR)-3,5-dichloro-6,6a-di-hydro-1aH-1-oxa-cyclopropa[a]indene(1215279-81-4)
• EPA Substance Registry System: (1aS,6aR)-3,5-dichloro-6,6a-di-hydro-1aH-1-oxa-cyclopropa[a]indene(1215279-81-4)

Safety Data

• Hazardous Substances Data: 1215279-81-4(Hazardous Substances Data)

Usage

Description

(1aS,6aR)-3,5-dichloro-6,6a-di-hydro-1aH-1-oxa-cyclopropa[a]indene is a cyclic organic compound characterized by the presence of chlorine atoms and a unique cyclopropa[a]indene ring structure. (1aS,6aR)-3,5-dichloro-6,6a-di-hydro-1aH-1-oxa-cyclopropa[a]indene features a heteroatom in its ring, contributing to its distinct chemical properties and potential reactivity. The molecular structure includes chlorine atoms at the 3rd and 5th positions, with an additional chlorine attached to the 6th carbon atom, making it a dihydro-1aH-1-oxa-cyclopropa[a]indene.

Uses

Used in Organic Synthesis:
(1aS,6aR)-3,5-dichloro-6,6a-di-hydro-1aH-1-oxa-cyclopropa[a]indene is utilized as a key intermediate in organic synthesis for the development of various chemical compounds. Its unique structural features and potential reactivity make it a valuable component in creating new molecules with specific properties.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, (1aS,6aR)-3,5-dichloro-6,6a-di-hydro-1aH-1-oxa-cyclopropa[a]indene is employed as a building block for the synthesis of drug candidates. Its distinct molecular structure may contribute to the development of novel therapeutic agents with improved efficacy and selectivity in treating various medical conditions.

Upstream product

• 52397-81-6 4,6-dichloroindan-1-one 
• 1188143-94-3 4,6-dichloroindan-1-ol 
• 52397-82-7 3-(2,4-dichlorophenyl)propanoyl chloride 
• 55144-92-8 3-(2,4-dichlorophenyl)propionic acid 
• 939760-78-8 5,7-dichloro-1H-indene 

Downstream Products

• 1215272-30-2 (R)-1-[(1S,2S)-4,6-dichloro-1-(4-methanesulfonylphenoxy)indan-2-yl]-3-fluoropyrrolidine 
• 1215273-25-8 (S)-1-[(1S,2S)-4,6-dichloro-1-(4-methanesulfonylphenoxy)indan-2-yl]-3-fluoropyrrolidine 

Relevant articles and documents

Discovery and Optimization of 1-Phenoxy-2-aminoindanes as Potent, Selective, and Orally Bioavailable Inhibitors of the Na+/H+ Exchanger Type 3 (NHE3)

The design, synthesis, and structure-activity relationship of 1-phenoxy-2-aminoindanes as inhibitors of the Na+/H+ exchanger type 3 (NHE3) are described based on a hit from high-throughput screening (HTS). The chemical optimization resulted in the discovery of potent, selective, and orally bioavailable NHE3 inhibitors with 13d as best compound, showing high in vitro permeability and lacking CYP2D6 inhibition as main optimization parameters. Aligning 1-phenoxy-2-aminoindanes onto the X-ray structure of 13d then provided 3D-QSAR models for NHE3 inhibition capturing guidelines for optimization. These models showed good correlation coefficients and allowed for activity estimation. In silico ADMET models for Caco-2 permeability and CYP2D6 inhibition were also successfully applied for this series. Moreover, docking into the CYP2D6 X-ray structure provided a reliable alignment for 3D-QSAR models. Finally 13d, renamed as SAR197, was characterized in vitro and by in vivo pharmacokinetic (PK) and pharmacological studies to unveil its potential for reduction of obstructive sleep apneas.

Indanyl-Substituted 4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridines, Their Use as Medicament, and Pharmaceutical Preparations Comprising Them

The invention relates to substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines of formula (I), their use as medicament, and pharmaceutical preparations comprising them. The compounds of formula (I) act on the TASK-1 potassium channel. The compounds are particularly suitable for the treatment or prevention of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.

INDANYL-SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDINES, THEIR USE AS MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM

The invention relates to substituted 4,5,6,7-tetrahydro-1 H-pyrazolo[4,3-c]pyridines of formula (I), their use as medicament, and pharmaceutical preparations comprising them. The compounds of formula (I) act on the TASK-1 potassium channel. The compounds are particularly suitable for the treatment or prevention of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.