121533-54-8

Basic information

• Product Name: (4S,5R)-3-tert-Butoxycarbonyl-4-cyclohexyl-methyl-2,2-dimethyloxazolidine-5-carboxylic acid
• Synonyms: (4S,5R)-3-tert-Butoxycarbonyl-4-cyclohexyl-methyl-2,2-dimethyloxazolidine-5-carboxylic acid
• CAS NO: 121533-54-8
• Molecular Weight: 341.448
• Mol File: 121533-54-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (4S,5R)-3-tert-Butoxycarbonyl-4-cyclohexyl-methyl-2,2-dimethyloxazolidine-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5R)-3-tert-Butoxycarbonyl-4-cyclohexyl-methyl-2,2-dimethyloxazolidine-5-carboxylic acid(121533-54-8)
• EPA Substance Registry System: (4S,5R)-3-tert-Butoxycarbonyl-4-cyclohexyl-methyl-2,2-dimethyloxazolidine-5-carboxylic acid(121533-54-8)

Safety Data

• Hazardous Substances Data: 121533-54-8(Hazardous Substances Data)

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 121533-55-9 (4S,5S)-3-tert-butoxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-5-vinyloxazolidine 
• 138448-18-7 [R-(R*,S*)]-β-[[(1,1-Dimethylethoxy)carbonyl]-amino]-α-(2-furanyl)cyclohexanepropanol 
• 98105-42-1 (S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal 
• 37736-82-6 (S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid 
• 138448-19-8 (4S-trans)-4-(cyclohexylmethyl)-5-(2-furanyl)-2,2-dimethyl-3-oxazolidinecarboxylic acid, 1,1-dimethylethyl ester 
• 115766-13-7 (S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]-N-methoxy-N-methylcyclohexanepropanamide 

Downstream Products

• 155381-81-0 (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-(3-iodo-propyl) ester 
• 134879-38-2 4-oxo-4-(phenylmethoxy)butyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarboxylate 
• 138448-17-6 (4S-trans)-4-(cyclohexylmethyl)-5-[[(methoxy)methylamino]carbonyl]-2,2-dimethyl-3-oxazolidinecarboxylic acid, 1,1-dimethylethyl ester 
• 134848-89-8 (8S,11S,12R)-11-(cyclohexylmethyl)-8-<ethoxy>carbonyl>-L-phenylalanyl>amino>-12-hydroxy-5,9,13-trioxo-1-oxa-4,10-diazacyclotridecane 
• 134848-66-1 (3R,4S,7S)-4-(cyclohexylmethyl)-7-<-L-phenylalanyl>amino>-3-hydroxy-2,6,10-trioxo-1-oxa-5,11-diazacyclotetradecane 
• 134848-65-0 (8S,11S,12R)-11-(cyclohexylmethyl)-8-<-L-phenylalanyl>amino>-12-hydroxy-5,9,13-trioxo-1-oxa-4,10-diazacyclotridecane 
• 134848-92-3 (3R,4S,7S)-4-(cyclohexylmethyl)-3-hydroxy-7-<<(phenylmethoxy)carbonyl>amino>-2,6,10-trioxo-1-oxa-5,11-diazacyclotetradecane 
• 134848-74-1 (8S,11S,12R)-11-(cyclohexylmethyl)-12-hydroxy-8-<<(phenylmethoxy)carbonyl>amino>-5,9,13-trioxo-1-oxa-4,10-diazacyclotridecane 
• 131316-86-4 (4S,5S)-5-((R)-2-Butylcarbamoyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-89-1 (4S,5S)-4-Cyclohexylmethyl-5-((E)-2-methoxycarbonyl-3-methyl-but-1-enyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-89-1 (4S,5S)-4-Cyclohexylmethyl-5-((Z)-2-methoxycarbonyl-3-methyl-but-1-enyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-95-9 (4S,5S)-4-Cyclohexylmethyl-5-((S)-2-methoxycarbonyl-3-methyl-butyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-93-7 (4S,5S)-4-Cyclohexylmethyl-5-((R)-2-methoxycarbonyl-3-methyl-butyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-90-4 (4S,5S)-5-((Z)-2-Butylcarbamoyl-3-methyl-but-1-enyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Relevant articles and documents

CYCLIC RENIN INHIBITORS CONTAINING 3(S)-AMINO-4-CYCLOHEXYL-2(R)-HYDROXY-BUTANOIC ACID OR 4-CYCLO-HEXYL-(2R,3S)-DIHYDROXYBUTANOIC ACID OR RELATED ANALOGS

Compounds of the formula: STR1 are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, and are useful in treating, preventing or managing renin-associated hypertension, hyperaldosteronism, congestive heart failure, and glaucoma.

Synthesis of the hydroxyethylene dipeptide isostere, (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

A stereoselective synthesis of the hydroxyethylene dipeptide isostere, (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid-n-butyl amide from Boc-L-phenylalanine is described.

Macrocyclic lactones having renin inhibiting properties

Compounds of the formula: