98105-42-1Relevant articles and documents
Immunoregulator
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Paragraph 0119; 0126-0128, (2021/11/26)
The invention discloses an immune regulator, in particular to a compound for inhibiting IL - 17A and application of the compound as an immunomodulator in preparation of medicines. The invention discloses a compound shown in formula I. The application of t
Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes
De Bruin, Gerjan,Huber, Eva M.,Xin, Bo-Tao,Van Rooden, Eva J.,Al-Ayed, Karol,Kim, Kyung-Bo,Kisselev, Alexei F.,Driessen, Christoph,Van Der Stelt, Mario,Van Der Marel, Gijsbert A.,Groll, Michael,Overkleeft, Herman S.
supporting information, p. 6197 - 6209 (2014/08/18)
Mammalian genomes encode seven catalytic proteasome subunits, namely, β1c, β2c, β5c (assembled into constitutive 20S proteasome core particles), β1i, β2i, β5i (incorporated into immunoproteasomes), and the thymoproteasome-specific subunit β5t. Extensive r
A direct and efficient stereoconservative procedure for the selective oxidation of N-protected β-amino alcohols
Ocejo, Marta,Vicario, Jose L.,Badía, Dolores,Carrillo, Luisa,Reyes, Efraim
, p. 2110 - 2112 (2007/10/03)
An efficient, very simple and eco-friendly procedure has been developed for the synthesis of highly enantioenriched α-amino aldehydes by IBX-mediated oxidation of the corresponding β-amino alcohols. The procedure has been applied to a wide range of substr