121788-91-8

Basic information

• Product Name: 3-Chlor-2-methyl-1-phenyl-2-(trimethylsiloxy)-1-propanon
• Synonyms: 3-Chlor-2-methyl-1-phenyl-2-(trimethylsiloxy)-1-propanon
• CAS NO: 121788-91-8
• Molecular Weight: 270.831
• Mol File: 121788-91-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Chlor-2-methyl-1-phenyl-2-(trimethylsiloxy)-1-propanon(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chlor-2-methyl-1-phenyl-2-(trimethylsiloxy)-1-propanon(121788-91-8)
• EPA Substance Registry System: 3-Chlor-2-methyl-1-phenyl-2-(trimethylsiloxy)-1-propanon(121788-91-8)

Safety Data

• Hazardous Substances Data: 121788-91-8(Hazardous Substances Data)

Upstream product

• 25438-37-3 phenyl(trimethylsiloxy)acetonitrile 
• 78-95-5 chloroacetone 

Downstream Products

• 49837-27-6 2,3-epoxy-2-methyl-1-phenylpropan-1-one 

Relevant articles and documents

Ttimethylsilyl Cyanide - A Reagent for Umpolung, XVIII. - Nucleophilic Acylation of α-Chlorocarbonyl Compounds - a Novel and Diastereoselective Approach to Substituted α,β-Epoxy Ketones

The addition products of trimethylsilyl cyanide and benzaldehyde (1a), furfural (1b), and α,β-unsaturated aldehydes 2a-c, respectively, react after deprotonation with α-chloroaldehydes and -ketones 3a-d.By 1,4-O,O-silyl rearrangement and cyanide elimination O-trimethylsilyl acyloins 4 and 9, respectively, are formed.With fluoride, 4 and 9 react to α,β-epoxy ketones 5 and 10 in high yield and with E/Z selectivities from 80:20 to >95:5.By this novel route even α,β-unsaturated epoxy ketones (10) become available.