1218-98-0

Basic information

• Product Name: 7,8-DIHYDRONEOPTERIN
• Synonyms: 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-1H-pteridin-4-one;2-azanyl-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-1H-pteridin-4-one;Dihydroneopterin;NEOPTERIN, 7,8-DIHYDRO-D;7,8-DIHYDRO-D-NEOPTERIN;7,8-DIHYDRONEOPTERIN
• CAS NO: 1218-98-0
• Molecular Formula: C₉H₁₃N₅O₄
• Molecular Weight: 255.23
• Product Categories: Heterocycles, Nucleotides, Bases & Related Reagents, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1218-98-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 614.6°Cat760mmHg
• Flash Point: 325.5°C
• Appearance: /
• Density: 2.03g/cm³
• Vapor Pressure: 1.13E-17mmHg at 25°C
• Refractive Index: 1.86
• Storage Temp.: −20°C
• Solubility: Aqueous Acid (Slightly), DMSO (Slightly)
• PKA: 9.88±0.20(Predicted)
• BRN: 1133875
• CAS DataBase Reference: 7,8-DIHYDRONEOPTERIN(CAS DataBase Reference)
• NIST Chemistry Reference: 7,8-DIHYDRONEOPTERIN(1218-98-0)
• EPA Substance Registry System: 7,8-DIHYDRONEOPTERIN(1218-98-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 1218-98-0(Hazardous Substances Data)

Usage

Description

7,8-Dihydroneopterin is a naturally occurring compound that serves as an intermediate in the biosynthesis of biopterin, a crucial cofactor for various enzymes involved in the metabolism of neurotransmitters and other biological processes. It is also an impurity found in neopterin, which is a precursor in the biosynthesis of biopterin.

Uses

Used in Pharmaceutical Industry:
7,8-Dihydroneopterin is used as a research compound for studying the biosynthesis of biopterin and its role in various biological processes. It is particularly useful in understanding the metabolic pathways and enzyme functions related to biopterin synthesis.
Used in Diagnostic Applications:
7,8-Dihydroneopterin can be used as a diagnostic marker to monitor the levels of biopterin and neopterin in biological samples. This can help in the identification and monitoring of certain genetic disorders and conditions that affect the metabolism of neurotransmitters.
Used in Biochemical Research:
7,8-Dihydroneopterin is used as a biochemical research tool to study the mechanisms of enzyme-catalyzed reactions involving biopterin and its precursors. It can also be used to investigate the role of biopterin in various cellular processes and its potential as a therapeutic target for certain diseases.

InChI:InChI=1/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1

Upstream product

• 86-01-1 Guanosine 5'-triphosphate 
• 2009-64-5 Neopterin 

Downstream Products

• 3672-03-5 7,8-dihydro-6-(hydroxymethyl)pterin 
• 141-46-8 Glycolaldehyde 
• 1131-35-7 7,8-dihydroxanthopterin 
• 13214-44-3 6-formyl-7,8-dihydropterin 
• 4033-27-6 (S)-2-{4-[(2-Amino-4-oxo-3,4,7,8-tetrahydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid 
• 135-16-0 (6S,S)-5,6,7,8-tetrahydrofolic acid 
• 3545-84-4 6-hydroxymethyl-7,8-dihydro-pterin pyrophosphate 

Related news

Effect of 7,8-DIHYDRONEOPTERIN (cas 1218-98-0) mediated CD36 down regulation and oxidant scavenging on oxidised low-density lipoprotein induced cell death in human macrophages07/20/2019

The role of CD36 in oxidised low-density lipoprotein (oxLDL) mediated cell death was examined by down regulating the receptor level with the macrophage generated antioxidant 7,8‐dihydroneopterin. Down regulation of CD36 protein levels in human monocyte derived macrophages by 7,8-dihydroneopteri...detailed

Relevant articles and documents

Synthesis of 5,6,7,8-Tetrahdro-D-neopterine tripolyphosphate. Attempt to Interpret the Biosynthesis of L-Sepiapterine

The synthesis was achieved by phosphorylation of tetrahydro-5,6,7,8-D-neopterine with polyphosphoric acid.The product is sensitive to light, moisture and oxidation like the other tetrahydropterines.After oxidation in aqueous solution, D,L-sepiapterine was isolated in 5percent yield.The oxidation of non-phosphorilated tetrahydro-5,6,7,8-D-neopterine under the same conditions led to D-sepiapterine without inversion of the configuration.These findings were used to give a tentative explanation for the biosynthesis of natural L-sepiapterine from the D-neopterine.