3672-03-5

Basic information

• Product Name: 6-Pteridinemethanol, 2-amino-7,8-dihydro-4-hydroxy-
• Synonyms: 6-Pteridinemethanol, 2-amino-7,8-dihydro-4-hydroxy-
• CAS NO: 3672-03-5
• Molecular Formula: C₇H₉N₅O₂
• Molecular Weight: 0
• Mol File: 3672-03-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 387.1°Cat760mmHg
• Flash Point: 187.9°C
• Appearance: /
• Density: 1.98g/cm³
• Vapor Pressure: 1.37E-07mmHg at 25°C
• Refractive Index: 1.892
• CAS DataBase Reference: 6-Pteridinemethanol, 2-amino-7,8-dihydro-4-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Pteridinemethanol, 2-amino-7,8-dihydro-4-hydroxy-(3672-03-5)
• EPA Substance Registry System: 6-Pteridinemethanol, 2-amino-7,8-dihydro-4-hydroxy-(3672-03-5)

Safety Data

• Hazardous Substances Data: 3672-03-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H9N5O2/c8-7-11-5-4(6(14)12-7)10-3(2-13)1-9-5/h13H,1-2H2,(H4,8,9,11,12,14)

Upstream product

• 1218-98-0 dihydro-7,8-D-neopterine 
• 712-29-8 6-(hydroxymethyl)pterin 

Downstream Products

• 490-79-9 2,5-dihydroxybenzoic acid. 
• 3545-84-4 6-hydroxymethyl-7,8-dihydro-pterin pyrophosphate 
• 135-16-0 (6S,S)-5,6,7,8-tetrahydrofolic acid 
• 3545-84-4 6-hydroxymethyl-7,8-pterin pyrophosphate 

Relevant articles and documents

A point mutation converts dihydroneopterin aldolase to a cofactor-independent oxygenase

Dihydroneopterin aldolase (DHNA) catalyzes the conversion of 7,8-dihydroneopterin (1) to 6-hydroxymethyl-7,8-dihydropterin (4) in the folate biosynthetic pathway. Substitution of a conserved tyrosine residue at the active site of DHNA by phenylalanine converts the enzyme to a cofactor-independent oxygenase, which generates mainly 7,8-dihydroxanthopterin (6) rather than 4. 6 is generated via the same enol intermediate as in the wild-type enzyme-catalyzed reaction, but this species undergoes an oxygenation reaction to form 6. The conserved tyrosine residue plays only a minor role in the formation of the enol reaction intermediate but a critical role in the protonation of the enol intermediate to form 4.