1219424-59-5

Basic information

• Product Name: 1-Benzyl-3-N-Cbz-amino-2,5-dioxo-pyrrolidine
• Synonyms: 1-Benzyl-3-N-Cbz-amino-2,5-dioxo-pyrrolidine;Benzyl (1-benzyl-2,5-dioxopyrrolidin-3-yl)
• CAS NO: 1219424-59-5
• Molecular Formula: C19H18N2O4
• Molecular Weight: 338
• Mol File: 1219424-59-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 597.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.31±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.29±0.20(Predicted)
• CAS DataBase Reference: 1-Benzyl-3-N-Cbz-amino-2,5-dioxo-pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-3-N-Cbz-amino-2,5-dioxo-pyrrolidine(1219424-59-5)
• EPA Substance Registry System: 1-Benzyl-3-N-Cbz-amino-2,5-dioxo-pyrrolidine(1219424-59-5)

Safety Data

• Hazardous Substances Data: 1219424-59-5(Hazardous Substances Data)

Usage

General Description

1-Benzyl-3-N-Cbz-amino-2,5-dioxo-pyrrolidine is a synthetic organic compound with a complex chemical structure. It is a pyrrolidine derivative that contains a benzyl group, an N-Cbz-protected amino group, and two carbonyl groups. 1-Benzyl-3-N-Cbz-amino-2,5-dioxo-pyrrolidine has potential applications in medicinal chemistry, particularly as a building block for the synthesis of pharmaceuticals or bioactive compounds. Its specific properties and potential uses would need to be determined through further research and experimentation.

Upstream product

• 100-46-9 benzylamine 
• 35739-00-5 benzyl (2,5-dioxotetrahydrofuran-3-yl)carbamate 
• 4515-21-3 N-benzyloxycarbonylaspartic acid 
• 501-53-1 benzyl chloroformate 
• 368875-04-1 N-benzyloxycarbonyl-D,L-asparagine n-butyl ester 
• 126401-11-4 N-benzyloxycarbonyl-D,L-asparagine ethyl ester 
• 160348-01-6 N-benzyloxycarbonyl-D,L-asparagine methyl ester 
• 29880-22-6 N-benzyloxy-carbonyl-DL-asparagine 
• 100-39-0 benzyl bromide 
• 160348-02-7 N-benzyloxycarbonyl-D-asparagine methyl ester 
• 88966-25-0 N-benzyloxycarbonyl-L-aspartic anhydride 
• 497-19-8 sodium carbonate 
• 4515-23-5 N-benzyloxycarbonyl-L-aspartic acid anhydride 
• 4668-37-5 N-(benzyloxycarbonyl)asparagine methyl ester 

Relevant articles and documents

Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-α Inhibitor

Tumor necrosis factor α (TNF-α) is an important therapeutic target for rheumatoid arthritis, inflammatory bowel disease, and septic hepatitis. In this study, structure-based virtual ligand screening combined with in vitro and in vivo assays were applied.

Chemo-enzymatic preparation of chiral 3-aminopyrrolidine derivatives

A new simple method for the enantioselective enzymatic hydrolysis of N-protected D-asparagine esters suitable for the use on the preparative scale is presented. Due to major obstacles observed under conventional reaction conditions - racemization of the retained ester and a strong enzyme inactivation - a comparatively low pH together with an organic co-solvent had to be employed. Under these conditions, nearly all tested proteases demonstrated good activity and excellent enantioselectivity giving access to the corresponding D-esters and L-asparagines in high optical purities (>95% ee) and good chemical yields (>40%). From the unnatural D-asparagine derivative, sequential cyclization, selective deprotection and reduction yielded efficiently benzyl protected (R)-3-aminopyrrolidine, a homo-chiral building block utilized in numerous drug candidates.

Process for producing 1H-3-aminopyrrolidine and derivatives thereof

A process for producing 1H-3-aminopyrrolidine and derivatives thereof is disclosed. The process is especially useful for producing optically active 1H-3-aminopyrrolidine and derivatives thereof and in this case comprises reacting an optically active amino