35739-00-5Relevant articles and documents
An expedient synthesis of non-racemic N-alkylated pyrrolidin-2,5-diones and piperidin-2,6-diones as peptidomimetics
Brethon, Anne,Bouix-Peter, Claire,Clary, Laurence,Fournier, Jean-Fran?ois,Harris, Craig S.,Lardy, Claude,Roche, Didier,Rodeschini, Vincent,Talano, Sandrine
, p. 5924 - 5927 (2016)
In our hands, access to 2 novel peptidomimetic scaffolds, based on N-alkylated pyrroldin-2,5-diones and piperidin-2,6-diones, proved to be much more challenging than anticipated. In this short communication, we disclose the strategies that we explored and
Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-α Inhibitor
Sun, Weiguang,Wu, Yanli,Zheng, Mengzhu,Yang, Yueying,Liu, Yang,Wu, Canrong,Zhou, Yirong,Zhang, Yonghui,Chen, Lixia,Li, Hua
, p. 8146 - 8156 (2020/09/21)
Tumor necrosis factor α (TNF-α) is an important therapeutic target for rheumatoid arthritis, inflammatory bowel disease, and septic hepatitis. In this study, structure-based virtual ligand screening combined with in vitro and in vivo assays were applied.
CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
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Page/Page column 268-270, (2008/06/13)
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
