1221-72-3

Basic information

• Product Name: [bis(4-methoxyphenyl)methylidene]diazenium
• CAS NO: 1221-72-3
• Molecular Formula: C₁₅H₁₄N₂O₂
• Molecular Weight: 255.2913
• Mol File: 1221-72-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: [bis(4-methoxyphenyl)methylidene]diazenium(CAS DataBase Reference)
• NIST Chemistry Reference: [bis(4-methoxyphenyl)methylidene]diazenium(1221-72-3)
• EPA Substance Registry System: [bis(4-methoxyphenyl)methylidene]diazenium(1221-72-3)

Safety Data

• Hazardous Substances Data: 1221-72-3(Hazardous Substances Data)

Usage

Description

[bis(4-methoxyphenyl)methylidene]diazenium, also known as GT-58, is a chemical compound belonging to the class of diazeniumdiolates. It is a donor-acceptor complex that functions as a nitric oxide releasing agent. [bis(4-methoxyphenyl)methylidene]diazenium has been investigated for its potential therapeutic applications, particularly in cardiovascular health and cancer treatment. Its controlled release of nitric oxide can positively impact blood vessel dilation, blood pressure regulation, and exhibit anti-proliferative activity against cancer cells. [bis(4-methoxyphenyl)methylidene]diazenium holds promise as a potential drug candidate for various medical conditions, with ongoing research aimed at further exploring its therapeutic potential.

Uses

Used in Cardiovascular Health Applications:
[bis(4-methoxyphenyl)methylidene]diazenium is used as a nitric oxide releasing agent for improving blood vessel dilation and blood pressure regulation. The controlled release of nitric oxide aids in maintaining proper cardiovascular function and overall heart health.
Used in Cancer Treatment Applications:
[bis(4-methoxyphenyl)methylidene]diazenium is used as an anti-proliferative agent against cancer cells. Its nitric oxide releasing property contributes to the inhibition of cancer cell growth, making it a potential therapeutic option for cancer treatment.
Used in Pharmaceutical Research:
[bis(4-methoxyphenyl)methylidene]diazenium is used as a potential drug candidate for various medical conditions. Ongoing research is being conducted to explore its therapeutic potential and develop novel drug delivery systems to enhance its efficacy and bioavailability in treating different health issues.

Upstream product

• 20114-55-0 4,4'-dimethoxybenzophenone hydrazone 
• 958-80-5 bis(4-methoxyphenyl)thione 
• 71-43-2 benzene 
• 90-96-0 bis(p-methoxyphenyl)methanone 

Downstream Products

• 17435-29-9 -bis-ethylxanthogenat 
• 533930-95-9 2-[bis(4-methoxyphenyl)methylene]-1,3,3-trimethylbicyclo[2.2.1]heptane 
• 131980-64-8 8-(4-methoxyphenyl)-5-methoxyindeno<1,2-d>-1,2,3-dithiazole 
• 208332-20-1 pentacarbonyl[bis(4-methoxyphenyl)carbene]chromium(O) 
• 1449328-70-4 C₂₇H₃₄N₂O₂ 
• 1648-06-2 4,4'-(2,2-difluoroethene-1,1-diyl)bis(methoxybenzene) 
• 84061-56-3 1,1,2,2,-tetrakis(p-methoxyphenyl)cyclopropane 
• 82186-14-9 (4aR,6S,7S,8R,8aR)-8-[Bis-(4-methoxy-phenyl)-methoxy]-6-methoxy-2,2-dimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 
• 4356-69-8 1,1-bis-(4-methoxyphenyl)ethylene 
• 1053-23-2 1,1,2,2-tetraphenylcyclopropane 
• 84061-55-2 1,1-bis(4-methoxyphenyl)-2,2-diphenylcyclopropane 
• 94258-89-6 5,5-bis-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazole-3,4-dicarboxylic acid anhydride 
• 1441324-00-0 4,4’-(((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)methylene)bis(methoxybenzene) 

Relevant articles and documents

Light and Temperature Control of the Spin State of Bis(p-methoxyphenyl)carbene: A Magnetically Bistable Carbene

Bis(p-methoxyphenyl)carbene is the first carbene that at cryogenic temperatures can be isolated in both its lowest energy singlet and triplet states. At 3 K, both states coexist indefinitely under these conditions. The carbene is investigated in argon mat

The First Crystal Structure of a Reactive Dirhodium Carbene Complex and a Versatile Method for the Preparation of Gold Carbenes by Rhodium-to-Gold Transmetalation

The dirhodium carbene derived from bis(4-methoxyphenyl)diazomethane and [Rh(tpa)4]·CH2Cl2 (tpa=triphenylacetate) was characterized by UV, IR, and NMR spectroscopy, HRMS, as well as by X-ray diffraction. The isolated comple

Copper-Mediated Cross-Coupling of Diazo Compounds with Sulfinates

A copper-mediated cross-coupling reaction between a diazo compound and a sodium alkane(arene)sulfinate gives a sulfone as the product. This reaction proceeds under mild conditions and features excellent functional group compatibility. A wide range of sodium alkane(arene)sulfinates were successfully applied in this chemistry. Mechanistic studies revealed that the overall reaction efficiency of the sulfinates was in line with their nucleophilicity in this reaction.

Efficient synthesis of ferrocifens and other ferrocenyl-substituted ethylenes: Via a 'sulfur approach'

Stable and non-odorous alkyl ferrocenyl thioketones react with bis(4-methoxyphenyl)diazomethane according to the 'two-fold extrusion' reaction principles, and tetrasubstituted ethylenes obtained thereby can be demethylated to give (Fc,2OH)-ferrocifens in good yields. The method offers an alternative approach to this class of medically relevant compounds. A similar protocol with alkyl ferrocenyl thioketones and selected diaryldiazomethanes leads to ferrocenyl-substituted ethylenes including dibenzofulvenes. These products are of potential interest for electrochemical and photophysical studies.