1222094-46-3

Basic information

• Product Name: 2-(4-chlorophenyl)-5-fluoroquinazoline
• Synonyms: 2-(4-chlorophenyl)-5-fluoroquinazoline
• CAS NO: 1222094-46-3
• Molecular Weight: 258.682
• Mol File: 1222094-46-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)-5-fluoroquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-5-fluoroquinazoline(1222094-46-3)
• EPA Substance Registry System: 2-(4-chlorophenyl)-5-fluoroquinazoline(1222094-46-3)

Safety Data

• Hazardous Substances Data: 1222094-46-3(Hazardous Substances Data)

Upstream product

• 771572-99-7 2-(aminomethyl)-4-fluoroaniline 
• 104-88-1 4-chlorobenzaldehyde 
• 434-76-4 2-amino-6-fluorobenzoic acid 
• 104-86-9 4-chlorobenzylamine 
• 221285-25-2 (2-amino-6-fluorophenyl)methanol 

Relevant articles and documents

Quinazoline synthesis method in water

The invention discloses a quinazoline synthesis method in water. The method comprises the steps that aldehyde, aminobenzylamine, a water-soluble complex catalyzer (an iridium or ruthenium complex catalyzer), solvent water and a reaction mixture are added in a container for several hours of reaction and cooled to the indoor temperature, rotary evaporation is carried out for removing a solvent, andcolumn separation is carried out to obtain a target compound. Compared with the reported documents, the method uses the water-soluble iridium or ruthenium complex catalyzer, the reaction only needs heating in the water and releases environmentally friendly hydrogen, an oxidizing agent or a hydrogen acceptor is not needed, and high economy and friendly environment of atoms are showed; therefore, the reaction conforms to the green chemistry requirements and has wide development prospects.

Highly efficient one-pot synthesis of 2-substituted quinazolines and 4H-benzo[d][1,3]oxazines via cross dehydrogenative coupling using sodium hypochlorite

This communication describes a catalyst-free synthesis of 2-substituted quinazolines and 4H-benzo[d][1,3]oxazines using commericially available sodium hypochlorite as oxidant. Operational simplicity, mild reaction conditions and the ability to construct structurally diverse 2-quinazolines and 2-substituted 4H-benzo[d][1,3]oxazines by this method render it to be a practical alternative for the synthesis of these heterocycles.