- Quinazoline synthesis method in water
-
The invention discloses a quinazoline synthesis method in water. The method comprises the steps that aldehyde, aminobenzylamine, a water-soluble complex catalyzer (an iridium or ruthenium complex catalyzer), solvent water and a reaction mixture are added in a container for several hours of reaction and cooled to the indoor temperature, rotary evaporation is carried out for removing a solvent, andcolumn separation is carried out to obtain a target compound. Compared with the reported documents, the method uses the water-soluble iridium or ruthenium complex catalyzer, the reaction only needs heating in the water and releases environmentally friendly hydrogen, an oxidizing agent or a hydrogen acceptor is not needed, and high economy and friendly environment of atoms are showed; therefore, the reaction conforms to the green chemistry requirements and has wide development prospects.
- -
-
Paragraph 0105; 0107; 0108
(2018/07/30)
-
- Iron-catalyzed cascade reaction of 2-aminobenzyl alcohols with benzylamines: Synthesis of quinazolines by trapping of ammonia
-
A novel approach to construct 2-aryl/heteroaryl quinazolines was developed through an iron-catalyzed cascade reaction of 2-aminobenzyl alcohols with benzylamines under aerobic oxidative conditions. The reaction proceeds via the formation of N-benzylideneb
- Gopalaiah, Kovuru,Saini, Anupama,Devi, Alka
-
p. 5781 - 5789
(2017/07/22)
-
- Highly efficient one-pot synthesis of 2-substituted quinazolines and 4H-benzo[d][1,3]oxazines via cross dehydrogenative coupling using sodium hypochlorite
-
This communication describes a catalyst-free synthesis of 2-substituted quinazolines and 4H-benzo[d][1,3]oxazines using commericially available sodium hypochlorite as oxidant. Operational simplicity, mild reaction conditions and the ability to construct structurally diverse 2-quinazolines and 2-substituted 4H-benzo[d][1,3]oxazines by this method render it to be a practical alternative for the synthesis of these heterocycles.
- Maheswari, C. Uma,Kumar, G. Sathish,Venkateshwar,Kumar, R. Arun,Kantam, M. Lakshmi,Reddy, K. Rajender
-
supporting information; experimental part
p. 341 - 346
(2010/04/28)
-