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1222368-75-3

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1222368-75-3 Usage

General Description

4-Bromo-2-(cyclopropylcarbonyl)-1-fluorobenzene is a chemical compound with the molecular formula C11H8BrFO. It is a halogenated aromatic compound with a cyclopropylcarbonyl group. 4-Bromo-2-(cyclopropylcarbonyl)-1-fluorobenzene is used as a building block in the synthesis of pharmaceuticals and other organic compounds. It has potential applications in medicinal chemistry, agrochemicals, and materials science. The cyclopropylcarbonyl group confers unique reactivity and steric properties to the molecule, making it valuable in the development of new drugs and materials. Additionally, the bromo and fluoro substituents make it a versatile intermediate for further chemical modifications and functional group transformations. Overall, 4-Bromo-2-(cyclopropylcarbonyl)-1-fluorobenzene has potential as a valuable synthetic building block with diverse applications in organic and medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 1222368-75-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,2,3,6 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1222368-75:
(9*1)+(8*2)+(7*2)+(6*2)+(5*3)+(4*6)+(3*8)+(2*7)+(1*5)=133
133 % 10 = 3
So 1222368-75-3 is a valid CAS Registry Number.

1222368-75-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (5-Bromo-2-fluorophenyl)(cyclopropyl)methanone

1.2 Other means of identification

Product number -
Other names (5-bromo-2-fluorophenyl)-cyclopropylmethanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1222368-75-3 SDS

1222368-75-3Relevant articles and documents

INHIBITORS OF ENL/AF9 YEATS

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Paragraph 00172-00173, (2021/06/26)

Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF9 YEATS and are therefore useful for treating leukemia.

3-AMINO-5-PHENYL-5,6-DIHYDRO-2H-[1,4]OXAZINES

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Page/Page column 33-34, (2011/04/14)

The present invention relates to 3-Amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. T

2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics

Zeng, Qingping,Bourbeau, Matthew P.,Wohlhieter, G. Erich,Yao, Guomin,Monenschein, Holger,Rider, James T.,Lee, Matthew R.,Zhang, Shiwen,Lofgren, Julie,Freeman, Daniel,Li, Chun,Tominey, Elizabeth,Huang, Xin,Hoffman, Douglas,Yamane, Harvey,Tasker, Andrew S.,Dominguez, Celia,Viswanadhan, Vellarkad N.,Hungate, Randall,Zhang, Xiaoling

scheme or table, p. 1652 - 1656 (2010/07/15)

A series of 2-aminothiadiazole of inhibitors of AKT1 is described. SAR relationships are discussed, along with selectivity for protein kinase A (PKA) and cyclin-dependent kinase 2 (CDK2). Moderate selectivity observed in several compounds for AKT1 versus PKA is rationalized by X-ray crystallographic analysis. Key compounds showed activity in cellular assays measuring phosphorylation of two AKT substrates, PRAS40 and FKHRL1. Compound 30 was advanced to a mouse liver PD assay, where it showed dose-dependent inhibition of AKT activity, as measured by the inhibition of phospho-PRAS40.

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