122334-37-6

Basic information

• Product Name: 4-CHLORO-N-METHOXY-N-METHYLACETAMIDE
• Synonyms: 4-CHLORO-N-METHOXY-N-METHYLACETAMIDE;4-CHLORO-N-METHOXY-N-METHYLBENZAMIDE;4-CHLORO-N-METHOXY-N-METYLBENZAMIDE;4-CLORO-N-MENTHOXY-N-METHYLBENZAMIDE;4-Chloro-N-Methyl-N-MethoxybenzaMide;N-Methoxy-N-methyl-4-chlorobenzamide;CLMMB 4-Chloro-n-methoxy-n-methylbenzamide
• CAS NO: 122334-37-6
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.63
• Mol File: 122334-37-6.mol
• Article Data: 71

Chemical Properties

• Boiling Point: 334.2 °C at 760 mmHg
• Flash Point: 155.9 °C
• Appearance: /
• Density: 1.224 g/cm³
• Vapor Pressure: 0.00013mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-CHLORO-N-METHOXY-N-METHYLACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-N-METHOXY-N-METHYLACETAMIDE(122334-37-6)
• EPA Substance Registry System: 4-CHLORO-N-METHOXY-N-METHYLACETAMIDE(122334-37-6)

Safety Data

• Hazardous Substances Data: 122334-37-6(Hazardous Substances Data)

Usage

Description

4-Chloro-N-methoxy-N-methylacetamide is a chemical compound that belongs to the class of amides. It is characterized by the presence of a chlorine atom at the 4-position, a methoxy group, and a methyl group attached to the nitrogen atom. 4-Chloro-N-methoxy-N-methylacetamide is a derivative of Ketamine, which is an intravenous anesthetic.

Uses

Used in Pharmaceutical Industry:
4-Chloro-N-methoxy-N-methylacetamide is used as an anesthetic agent for its ability to induce a state of pain relief and sedation. It is particularly useful in medical procedures that require intravenous anesthesia, providing a safe and effective means of managing pain and discomfort during surgery or other medical interventions.
Additionally, due to its structural similarity to Ketamine, 4-Chloro-N-methoxy-N-methylacetamide may also have potential applications in the development of new anesthetic drugs or in the study of the mechanisms of action of existing anesthetic agents. This could lead to the discovery of more effective and safer anesthetics for various medical applications.

InChI:InChI=1/C9H10ClNO2/c1-11(13-2)9(12)7-3-5-8(10)6-4-7/h3-6H,1-2H3

Upstream product

• 1613-83-8 N-methyl-N-(4-chlorobenzoyl)hydroxylamine 
• 6214-20-6 methyl 4-nitrobenzenesulfonate 
• 6213-85-0 Methyl 4-brosylate 
• 6214-19-3 methyl p-methoxybenzenesulfonate 
• 6214-21-7 methyl m-nitrobenzenesulphonate 
• 21447-62-1 3-Nitro-4-methyl-benzolsulfonsaeuremethylester 
• 565-45-7 methyl p-fluorobenzenesulphonate 
• 80-48-8 methyl p-toluene sulfonate 
• 80-18-2 Methyl benzenesulfonate 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 74-11-3 para-chlorobenzoic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 33613-52-4 dimethylphenyl sulfonium tetrafluoroborate 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 
• 147030-64-6 4'-chloro-3-(1,3-dioxolan-2-yl)propiophenone 
• 25017-08-7 1-(4-chlorophenyl)pentan-1-one 
• 99-91-2 para-chloroacetophenone 
• 90269-48-0 1-(4-chlorophenyl)-2-methylbutan-1-one 
• 406162-21-8 (4-chlorophenyl)-[4-(3-chlorophenyl)-2-methoxyquinolin-6-yl]methanone 
• 807614-69-3 (2-chloro-3-methyl-3H-imidazol-4-yl)(4-chlorophenyl)methanone 
• 81223-74-7 p-chlorobenzoyl-6 indole 
• 7295-50-3 1-(4-chlorophenyl)hexan-1-one 
• 126314-18-9 4-phenyl-1-(p-chlorophenyl)-1-butanone 
• 51490-05-2 1,2-bis(4-chlorophenyl)ethanone 
• 654682-18-5 1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)ethanone 
• 106970-98-3 3-(4-chlorophenyl)-3-oxopropionic acid tert-butyl ester 
• 952019-72-6 2-acetyl-3-(4-chlorobenzoyl)succinic acid 4-tert-butyl ester 1-ethyl ester 

Relevant articles and documents

Phase-Transfer Catalyzed Asymmetric [4 + 1] Annulations for the Synthesis of Chiral 2,2-Disubstituted Tetrahydrothiophenes

An efficient catalytic asymmetric [4 + 1] reaction, which features the use of simple β-keto esters as one-carbon nucleophiles and 5-succinimidothio-pent-2-enoates as four-atom bielectrophiles, has been developed in the presence of a bifunctional chiral ph

A CO2-Catalyzed Transamidation Reaction

Transamidation reactions are often mediated by reactive substrates in the presence of overstoichiometric activating reagents and/or transition metal catalysts. Here we report the use of CO2as a traceless catalyst: in the presence of catalytic amounts of CO2, transamidation reactions were accelerated with primary, secondary, and tertiary amide donors. Various amine nucleophiles including amino acid derivatives were tolerated, showcasing the utility of transamidation in peptide modification and polymer degradation (e.g., Nylon-6,6). In particular,N,O-dimethylhydroxyl amides (Weinreb amides) displayed a distinct reactivity in the CO2-catalyzed transamidation versus a N2atmosphere. Comparative Hammett studies and kinetic analysis were conducted to elucidate the catalytic activation mechanism of molecular CO2, which was supported by DFT calculations. We attributed the positive effect of CO2in the transamidation reaction to the stabilization of tetrahedral intermediates by covalent binding to the electrophilic CO2

Iron-Catalyzed, Iminyl Radical-Triggered Cascade 1,5-Hydrogen Atom Transfer/(5+2) or (5+1) Annulation: Oxime as a Five-Atom Assembling Unit

By integration of iminyl radical-triggered 1,5-hydrogen atom transfer and (5+2) or (5+1) annulation processes, a series of structurally novel and interesting azepine and spiro-tetrahydropyridine derivatives have been successfully prepared in moderate to good yields. This method utilizes FeCl2 as the catalyst and readily available oximes as five-atom units, while showcasing broad substrate scope and good functional group compatibility. The annulation products can be easily converted into many valuable compounds. Moreover, DFT calculation studies are performed to provide some insights into the possible reaction mechanisms for the (5+2) and (5+1) annulations.