7295-50-3Relevant articles and documents
Preparation method of aryl ketone compound
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Paragraph 0041-0049; 0061-0065; 0067, (2022/04/16)
The invention provides a preparation method of an aryl ketone compound, and belongs to the technical field of compound synthesis. The method comprises the following steps: under the action of a silver catalyst and water, carrying out reaction on aryl alkyne with a structure as shown in a formula 1 in a solvent at 60-120 DEG C for 12-48 hours, and separating and purifying a product after the reaction is finished, so as to obtain the single aryl ketone compound with a structure as shown in a formula I, the raw materials are easy to obtain, the experimental operation is simple, the yield of the prepared single aryl ketone compound is good, and gram-scale experiments can be carried out.
CARBOXY DERIVATIVES WITH ANTIINFLAMMATORY PROPERTIES
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Page/Page column 247; 248, (2021/07/02)
The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: (I) wherein, RA1, RA2, RC and RD are as defined herein.
An Efficient α-alkylation of aromatic ketones with primary alcohols catalyzed by [cp*ircl2]2 without solvent
Li, Jian,Zhang, Weixing,Wang, Feng,Jiang, Min,Dong, Xiaochun,Zhao, Weili
, p. 2363 - 2366,4 (2020/09/16)
Aromatic ketones are directly alkylated at α position with primary alcohols at 110°C in the presence of catalytic amount of KOH and [Cp*IrCl2]2 (Cp=pentamethylcyclopentadienyl) catalyst. The reaction is carried out in the absence of any solvent or additive, which generates only water as the byproduct in theory. It is very efficient and generally completed in 10 min in good isolated yields. The reaction is believed to undergo successive hydrogen transfer and cross aldol condensation processes. Copyright