122770-40-5

Basic information

• Product Name: 1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-fluorophenyl)-
• CAS NO: 122770-40-5
• Molecular Formula: C14H15FO2
• Molecular Weight: 234.27
• Mol File: 122770-40-5.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-fluorophenyl)-(122770-40-5)
• EPA Substance Registry System: 1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4-fluorophenyl)-(122770-40-5)

Safety Data

• Hazardous Substances Data: 122770-40-5(Hazardous Substances Data)

Upstream product

• 680596-79-6 4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane 
• 1580472-97-4 potassium (1,4-dioxaspiro[4.5]dec-7-en-8-yl)trifluoroborate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-34-1 4-fluoro-1-iodobenzene 
• 352-32-9 p-fluorotoluene 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 122770-39-2 4-(4-fluorophenyl)-4-hydroxy-cyclohexanone ethylene ketal 
• 1765-93-1 4-fluoroboronic acid 
• 170011-47-9 1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate 

Downstream Products

• 1402080-50-5 5-(4-fluorophenyl)oxepan-2-one 
• 36716-73-1 4-(p-fluorophenyl)-3-cyclohexen-1-one 
• 40503-86-4 1-(4-Fluoro-phenyl)-4-cyclohexanone 
• 1344674-51-6 2-(4-(4-fluorophenyl)cyclohexylidene)-1-(4-iodobenzyl)-1-phenylhydrazine 
• 1344674-29-8 (S)-3-(4-fluorophenyl)-9-(4-iodobenzyl)-2,3,4,9-tetrahydro-1H-carbazole 
• 80912-56-7 8-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]decane 

Relevant articles and documents

Cobalt-Catalyzed Desymmetric Isomerization of Exocyclic Olefins

Chiral cyclic olefins, 1-methylcyclohexenes, are versatile building blocks for the synthesis of pharmaceuticals and natural products. Despite the prevalence of these structural motifs, the development of efficient synthetic methods remains an unmet challenge. Herein we report a novel desymmetric isomerization of exocyclic olefins using a series of newly designed chiral cobalt catalysts, which enables a straightforward construction of chiral 1-methylcyclohexenes with diversified functionalities. The synthetic utility of this methodology is highlighted by a concise and enantioselective synthesis of a natural product, β-bisabolene. The versatility of the reaction products is further demonstrated by multifarious derivatizations.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

NOVEL 5 or 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS SELECTIVE INHIBITORS OF INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES

Disclosed herein are 5 or 8-substituted imidazo [1, 5-a] pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo [1, 5-a] pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo [1, 5-a] pyridines that can be useful for inhibiting indoleamine 2, 3-dioxygenase and/or tryptophane 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.