1227923-29-6

Basic information

• Product Name: 3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]benzo[h]quinazolin-4(3H)-one
• Synonyms: 3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]benzo[h]quinazolin-4(3H)-one;M1 receptor;MK 7622;MK7622;MK-7622;3-((1S,2S)-2-hydroxycyclohexyl)-6-((6-Methylpyridin-3-yl)Methyl)benzo[h]quinazolin-4(3H)-one;M1 receptor modulator;3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]quinazolin-4-one
• CAS NO: 1227923-29-6
• Molecular Formula: C₂₅H₂₅N₃O₂
• Molecular Weight: 399.4849
• Mol File: 1227923-29-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.30
• CAS DataBase Reference: 3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]benzo[h]quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]benzo[h]quinazolin-4(3H)-one(1227923-29-6)
• EPA Substance Registry System: 3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]benzo[h]quinazolin-4(3H)-one(1227923-29-6)

Safety Data

• Hazardous Substances Data: 1227923-29-6(Hazardous Substances Data)

Usage

General Description

3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]benzo[h]quinazolin-4(3H)-one is a complex organic compound belonging to the class of benzoquinazolines, featuring a quinazoline core with substitutions at positions 3 and 6. Elements present in this compound include carbon, hydrogen, nitrogen and oxygen. Its chemical structure includes a cyclohexyl ring - a six carbon-ring structure with the 2-hydroxy substitution, a pyridine ring, and a benzo[h]quinazolin-4(3H)-one core with an additional benzene ring. Detailed information about the chemical, including its physical and chemical properties, uses, and potential safety hazards, is yet to be reported in scientific literature.

Upstream product

• 1268515-63-4 methyl 1-amino-4-bromo-2-naphthoate hydrobromide 
• 35092-83-2 methyl 1-amino-2-naphthoate 
• 78508-71-1 methyl 1-nitro-2-naphthoate 
• 931-15-7 (1S,2S)-trans-2-aminocyclohexanol 
• 103987-83-3 1-nitro-2-naphthoic acid 
• 339015-80-4 Dimethyl-[(E)-2-(1-nitro-naphthalen-2-yl)-vinyl]-amine 
• 881-03-8 1-nitro-2-methylnaphthalene 
• 34101-77-4 5-acetoxymethyl-2-methyl-pyridine 
• 1227924-49-3 3-((1S,2S)-2-hydroxycyclohexyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)benzo[h]quinazolin-4(3H)-one 
• 1227924-44-8 6-bromo-3-[(1S,2S)-2-hydroxycyclohexyl]benzo[h]quinazolin-4(3H)-one 
• 1227924-43-7 1-amino-4-bromo-N-[(1S,2S)-2-hydroxycyclohexyl]-2-naphthamide 
• 1227924-42-6 1-amino-4-bromo-2-naphthoic acid 
• 4919-43-1 1-amino-2-naphthoic acid 
• 1227923-94-5 6-((6-chloropyridin-3-yl)methyl)-3-((1S,2S)-2-hydroxycyclohexyl)benzo[h]quinazolin-4(3H)-one 

Downstream Products

• 1371535-86-2 3-((1S,2S)-2-((tert-butyldimethylsilyl)oxy)cyclohexyl)-6-((6-methylpyridin-3-yl)methyl)benzo[h]quinazolin-4(3H)-one 
• 1371535-87-3 3-((1S,2S)-2-((tert-butyldimethylsilyl)oxy)cyclohexyl)-6-((6-methylpyridin-3-yl)methyl)-2,3-dihydrobenzo[h]quinazolin-4(1H)-one 

Relevant articles and documents

MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate

Identification of ligands that selectively activate the M1 muscarinic signaling pathway has been sought for decades to treat a range of neurological and cognitive disorders. Herein, we describe the optimization efforts focused on addressing key physicochemical and safety properties, ultimately leading to the clinical candidate MK-7622, a highly selective positive allosteric modulator of the M1 muscarinic receptor that has entered Phase II studies in patients with Alzheimer's disease.

DIHYDROBENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention is directed to dihydrobenzoquinazilinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease