4919-43-1

Basic information

• Product Name: 1-aminonaphthalene-2-carboxylic acid
• Synonyms: 1-aminonaphthalene-2-carboxylic acid;1-Amino-2-naphthoic acid;1-Amino-2-naphthalenecarboxylic acid;1-aminophthalene-2-carboxylic acid
• CAS NO: 4919-43-1
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.2
• Mol File: 4919-43-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 205-206℃
• Boiling Point: 378.5±30.0 °C(Predicted)
• Appearance: /
• Density: 1.352±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.02±0.10(Predicted)
• CAS DataBase Reference: 1-aminonaphthalene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-aminonaphthalene-2-carboxylic acid(4919-43-1)
• EPA Substance Registry System: 1-aminonaphthalene-2-carboxylic acid(4919-43-1)

Safety Data

• Hazardous Substances Data: 4919-43-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Medicinal Chemistry, 37, p. 745, 1994 DOI: 10.1021/jm00032a007

Upstream product

• 91-57-6 2-Methylnaphthalene 
• 6247-12-7 1,3-dihydro-2H-benzo[g]indol-2-one 
• 86-57-7 1-Nitronaphthalene 
• 151-50-8 potassium cyanide 
• 339015-80-4 Dimethyl-[(E)-2-(1-nitro-naphthalen-2-yl)-vinyl]-amine 
• 5353-96-8 6,7-benzoisatin 
• 99847-19-5 (1-nitro-[2]naphthyl)-pyruvic acid 
• 3100-67-2 1-amino-2-naphthalenecarbonitrile 
• 103987-83-3 1-nitro-2-naphthoic acid 
• 575-36-0 1-acetamidonaphthalene 
• 881-03-8 1-nitro-2-methylnaphthalene 

Downstream Products

• 134-32-7 1-amino-naphthalene 
• 153684-35-6 2-phenyl-4H-naphth<1,2-d><1,3>oxazin-4-one 
• 1227924-42-6 1-amino-4-bromo-2-naphthoic acid 
• 1227924-43-7 1-amino-4-bromo-N-[(1S,2S)-2-hydroxycyclohexyl]-2-naphthamide 
• 1227924-44-8 6-bromo-3-[(1S,2S)-2-hydroxycyclohexyl]benzo[h]quinazolin-4(3H)-one 
• 1371535-86-2 3-((1S,2S)-2-((tert-butyldimethylsilyl)oxy)cyclohexyl)-6-((6-methylpyridin-3-yl)methyl)benzo[h]quinazolin-4(3H)-one 
• 1227923-29-6 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]quinazolin-4(3H)-one 
• 1227924-49-3 3-((1S,2S)-2-hydroxycyclohexyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)benzo[h]quinazolin-4(3H)-one 
• 1598130-46-1 2,4‐dichlorobenzo[h]quinazoline 
• 4786-80-5 2?chloro?4-phenylbenzoquinazoline 
• 912365-38-9 1-aminonaphth-1-ylmethanol 
• 176853-41-1 1-amino naphthalene-2-carboxaldehyde 

Relevant articles and documents

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Anthranilic acid and derivatives thereof as well as synthesis method and application thereof

In the reaction solvent, o-methyl (hetero) aryl nitro compound is taken as a reaction raw material and is used for water. The anthranilic acid and its derivatives are synthesized by the action of a catalyst, a base and an additive. The synthetic method has the advantages of cheap and easily available raw materials, simple reaction operation, high yield and excellent functional group tolerance, and provides a simple and efficient method for synthesizing o-aminobenzoic acid which is widely used in the aspects of dyes, medicines, pesticides, spices and the like. The invention further discloses the anthranilic acid and derivatives and application thereof, and has a wide application prospect.

PROCESS FOR MAKING M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

This invention provides novel processes for the preparation of compounds such as 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]-quinazolin-4(3H)-one, salts and derivatives thereof. The compounds synthesized by the processes of the invention are useful for treating Alzheimer's disease and other diseases (e.g., cognitive impairment, schizophrenia, pain disorders, and sleep disorders) mediated by the muscarinic M1 receptor.