1228384-78-8

Basic information

• Product Name: 8-[4-(cyclopentyloxy)-3-methoxyphenyl]-3-methyl-1-propylxanthine
• CAS NO: 1228384-78-8
• Molecular Weight: 398.462
• Mol File: 1228384-78-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-[4-(cyclopentyloxy)-3-methoxyphenyl]-3-methyl-1-propylxanthine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-[4-(cyclopentyloxy)-3-methoxyphenyl]-3-methyl-1-propylxanthine(1228384-78-8)
• EPA Substance Registry System: 8-[4-(cyclopentyloxy)-3-methoxyphenyl]-3-methyl-1-propylxanthine(1228384-78-8)

Safety Data

• Hazardous Substances Data: 1228384-78-8(Hazardous Substances Data)

Upstream product

• 2434-53-9 6-amino-1-methyluracil 
• 63981-33-9 6-amino-1-methyl-3-propyl-1,3-dihydropyrimidine-2,4-dione 
• 106465-68-3 5,6-diamino-1-methyl-3-n-propyluracil 
• 197573-17-4 4-cyclopentyloxy-3-methoxy-benzaldehyde 
• 106465-67-2 6-amino-1-methyl-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione 
• 121-33-5 vanillin 
• 341487-55-6 N'-(1,2,3,6-tetrahydro-3-methyl-2,6-dioxo-1-propylpyrimidin-4-yl)-N,N-dimethylformamidine 

Relevant articles and documents

Synthesis of 8-(cyclopentyloxy)phenyl substituted xanthine derivatives as adenosine A2A ligands

The present paper describes the synthesis of a series of 8-(cyclopentyloxy)phenyl-xanthines and their evaluation for affinity for A 1 and A2 adenosine receptors using radioligand binding assays. The effects of moving the cyclopentyloxy substituent with or without an ortho methoxy group on the various positions of the 8-phenyl ring have been studied. The vanilloid based xanthines 8-[4-(cyclopentyloxy)-3-methoxyphenyl]-1, 3-dimethylxanthine (6a) (Ki = 100 nM) and 8-[(4-cyclopentyloxy)-3- methoxyphenyl]-3-methyl-1-propylxanthine (12) (Ki = 150 nM) displayed the highest affinity at A2A receptors as well as over 1000 fold selectivity over the A1 adenosine receptor subtype. ECV · Editio Cantor Verlag, Aulendorf (Germany).