122853-43-4Relevant articles and documents
Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists
Weichert, Dietmar,Stanek, Markus,Hübner, Harald,Gmeiner, Peter
, p. 2641 - 2653 (2016)
Aiming to discover dual-acting β2 adrenergic/dopamine D2 receptor ligands, a structure-guided approach for the evolution of GPCR agonists that address multiple targets was elaborated. Starting from GPCR crystal structures, we describ
Ethers and thioethers having therapeutical activity, their preparation and pharmaceutical compositions containing them
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, (2008/06/13)
Compounds of formula I STR1 wherein Ar is an optionally substituted phenyl ring; B is a single bond, a group --(CH2 OCH2)n being n=1 or 2, a 2,4-disubstituted-1,3-dioxolane ring or a 2,4-disubstituted-1,3-thioxolane ring, R is a single bond, an optionally substituted methylene or ethylene group and T is 2-, 3- or 4-pyridyl, an optionally salified or esterified carboxy group or a carboxyamide group. Said compounds are useful in treatment of respiratory diseases.