1229224-93-4 Usage
General Description
Cinacalcet Impurity is a group of related chemicals that are impurities or by-products of the synthesis of the drug cinacalcet, which is primarily used to treat secondary hyperparathyroidism and parathyroid carcinoma. These impurities can include various compounds such as cinacalcet-related substances A, B, C, and D, as well as other unidentified impurities. It is important to monitor and control the levels of these impurities in cinacalcet formulations, as they can potentially affect the safety and efficacy of the drug. Regulatory agencies such as the US Food and Drug Administration (FDA) have guidelines in place for monitoring and controlling impurities in pharmaceutical products like cinacalcet to ensure their quality and safety for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 1229224-93-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,9,2,2 and 4 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1229224-93:
(9*1)+(8*2)+(7*2)+(6*9)+(5*2)+(4*2)+(3*4)+(2*9)+(1*3)=144
144 % 10 = 4
So 1229224-93-4 is a valid CAS Registry Number.
1229224-93-4Relevant articles and documents
HIGHLY PURE CINACALCET OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
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Page/Page column 46, (2010/07/02)
Provided herein are impurities of cinacalcet, (R)-α-methyl-N-[3-[3-(trifluoromethyl) phenyl]propyl]-1-(5,6,7,8-tetrahydronaphthalene)methaneamine (tetrahydro cinacalcet impurity), (R)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1- naphthalenemethaneamine-N-oxide (cinacalcet N-oxide impurity) and (R)-α-methyl-N-[3-[3- (trifiuoromethyl)phenyl]methyl]-1-naphthalenemethaneamine (benzylamine impurity); and processes for preparation and isolation thereof. Provided further herein is a highly pure cinacalcet or a pharmaceutically acceptable salt thereof substantially free of impurities, processes for the preparation thereof, and pharmaceutical compositions comprising highly pure cinacalcet or a pharmaceutically acceptable salt thereof substantially free of impurities.
