1233735-48-2

Basic information

• Product Name: 1-(1-phenyl-1H-imidazol-2-yl)propan-1-one
• Synonyms: 1-(1-phenyl-1H-imidazol-2-yl)propan-1-one
• CAS NO: 1233735-48-2
• Molecular Weight: 200.24
• Mol File: 1233735-48-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-(1-phenyl-1H-imidazol-2-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-phenyl-1H-imidazol-2-yl)propan-1-one(1233735-48-2)
• EPA Substance Registry System: 1-(1-phenyl-1H-imidazol-2-yl)propan-1-one(1233735-48-2)

Safety Data

• Hazardous Substances Data: 1233735-48-2(Hazardous Substances Data)

Upstream product

• 7164-98-9 1-phenylimidazole 
• 123-62-6 propionic acid anhydride 
• 554-12-1 propanoic acid methyl ester 
• 758-96-3 N,N-dimethyl-propanamide 
• 104863-65-2 N-methyl-N-methoxypropionamide 

Downstream Products

• 1233735-59-5 (Z)-2-methylallyl 1-(1-phenyl-1H-imidazol-2-yl)prop-1-enyl carbonate 
• 1233735-62-0 (E)-penta-2,4-dien-1-yl ((Z)-1-(1-phenyl-1H-imidazol-2-yl)prop-1-en-1-yl) carbonate 
• 1233735-60-8 (Z)-cyclopent-2-enyl 1-(1-phenyl-1H-imidazol-2-yl)prop-1-enyl carbonate 
• 1233735-61-9 (Z)-cyclohex-2-enyl 1-(1-phenyl-1H-imidazol-2-yl)prop-1-enyl carbonate 
• 1233735-49-3 (Z)-allyl 1-(1-phenyl-1H-imidazol-2-yl)prop-1-enyl carbonate 

Relevant articles and documents

Catalytic Enantioselective Oxidative Homocoupling of 2-Acyl Imidazoles

A diastereoselective and enantioselective construction of 2,3-disubstituted 1,4-dicarbonyl compounds is reported. Nishiyama's RuPhebox complex (2.0 mol% catalyst loading) serves as a chiral Lewis acid catalyst in conjunction with BrCCl3 and a base for the oxidative homocoupling of 2-acyl imidazoles via the stereocontrolled reaction of intermediate Ru enolates with in situ brominated 2-acyl imidazoles. Cleavage of the achiral imidazole auxiliary provides optically active 2,3-disubstituted succinic acids which are useful intermediates in the synthesis of chiral compounds like the natural product class of lignans. (Figure presented.).

Catalytic Enantioselective α-Fluorination of 2-Acyl Imidazoles via Iridium Complexes

The first highly enantioselective α-fluorination of 2-acyl imidazoles utilizing iridium catalysis has been accomplished. This transformation features mild conditions and a remarkably broad substrate scope, providing an efficient and highly enantioselective approach to obtain a wide range of fluorine-containing 2-acyl imidazoles which are found in a variety of bioactive compounds and prodrugs. A large scale synthesis has also been tested to demonstrate the potential utility of this fluorination method.

Enantioselective, catalytic trichloromethylation through visible-light-activated photoredox catalysis with a chiral iridium complex

An enantioselective, catalytic trichloromethylation of 2-acyl imidazoles and 2-acylpyridines is reported. Several products are formed with enantiomeric excess of ≥99%. In this system, a chiral iridium complex serves a dual function, as a catalytically active chiral Lewis acid and simultaneously as a precursor for an in situ assembled visible-light-triggered photoredox catalyst.