1235863-07-6Relevant articles and documents
Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited
Tang, Jing,Maddali, Kasthuraiah,Pommier, Yves,Sham, Yuk Y.,Wang, Zhengqiang
supporting information; experimental part, p. 3275 - 3279 (2010/08/19)
A series of dihydroxypyrimidine (DHP) derivatives were designed as inhibitors of HIV integrase (IN) based on known homology models. Through chemical synthesis and biochemical assays it was found that the activity profile of these compounds largely deviate