1235863-10-1Relevant articles and documents
Design and synthesis of N-methylpyrimidone derivatives as HIV-1 integrase inhibitors
Wang, Yujie,Rong, Jie,Zhang, Bin,Hu, Liming,Wang, Xiaoli,Zeng, Chengchu
, p. 735 - 741 (2015/02/19)
A series of novel β-diketo derivatives which combined the virtues of dihydroxypyrimidine carboxamide derived from the evolution of DKA and polyhydroxylated aromatics moieties, were designed and synthesized as potential HIV-1 integrase (IN) inhibitors and
Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited
Tang, Jing,Maddali, Kasthuraiah,Pommier, Yves,Sham, Yuk Y.,Wang, Zhengqiang
supporting information; experimental part, p. 3275 - 3279 (2010/08/19)
A series of dihydroxypyrimidine (DHP) derivatives were designed as inhibitors of HIV integrase (IN) based on known homology models. Through chemical synthesis and biochemical assays it was found that the activity profile of these compounds largely deviate
