1237737-87-9

Basic information

• Product Name: 4-(6-ethylbenzothiazol-2-yl)phenylamine
• Synonyms: 4-(6-ethylbenzothiazol-2-yl)phenylamine
• CAS NO: 1237737-87-9
• Molecular Weight: 254.356
• Mol File: 1237737-87-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(6-ethylbenzothiazol-2-yl)phenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(6-ethylbenzothiazol-2-yl)phenylamine(1237737-87-9)
• EPA Substance Registry System: 4-(6-ethylbenzothiazol-2-yl)phenylamine(1237737-87-9)

Safety Data

• Hazardous Substances Data: 1237737-87-9(Hazardous Substances Data)

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 90382-10-8 2-amino-5-ethylbenzothiazole 
• 62-23-7 4-nitro-benzoic acid 
• 1257874-87-5 N-(4-ethylphenyl)-4-nitrothiobenzamide 
• 199107-79-4 N-(4-ethylphenyl)-4-nitrobenzamide 
• 589-16-2 4-aminoethylbenzene 
• 1237737-84-6 6-ethyl-2-(4-nitrophenyl)benzothiazole 

Relevant articles and documents

Synthesis of 2-(4-aminophenyl)benzothiazoles using MF resin supported H+ under solvent free conditions

Abstract A simple and convenient approach to 2-(4-aminophenyl)benzothiazole derivatives by condensation of o-aminothiophenol with (un)substituted p-aminobenzoic acid under the action of melamine formaldehyde resin (MFR) supported sulfuric acid under microwave irradiation (MW) and solvent-free conditions has been developed. Structures of the corresponding products were elucidated by IR, 1H NMR spectra, and elemental analysis. The resin could be easily recovered and reused for subsequent reactions.

Synthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents

Photodynamic therapy (PDT) employing exogenous photosensitizers is currently being approved for treatment of basal cell carcinoma (BCC). 2-(4-Aminophenyl)benzothiazoles (6) consist of chromophoric structure and absorb light in the UVA (315-400 nm). These results encouraged us to design and synthesize a diversity of 2-phenylbenzothiazoles (6). Studies on the apoptotic mechanism involved in photosensitive effects induced by UVA-activated 6 in BCC cells are carried out in the present article. 6-UVA-treated cells displayed several features of apoptosis, including an increase in the sub-G1 population, a significantly increased annexin V binding, and activation of caspase-3. 6-UVA induced a decrease in mitochondrial membrane potential (Δψ mt) and ATP via enhanced ROS generation and promoted phosphorylation of extracellular signal-regulated kinase (ERK) and p38 MAPK expression. These results suggest that 6-UVA elicits photosensitive effects in mitochondria processes which involve ERK and p38 activation, and ultimately lead to BCC cell apoptosis.