123843-66-3

Basic information

• Product Name: 2,6-DIFLUORO-4-METHOXYBENZONITRILE
• Synonyms: 2,6-DIFLUORO-4-METHOXYBENZONITRILE;3,5-Difluoro -4-cyanoanisole
• CAS NO: 123843-66-3
• Molecular Formula: C₈H₅F₂NO
• Molecular Weight: 169.13
• Product Categories: Aromatic Nitriles
• Mol File: 123843-66-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 53-57℃
• Boiling Point: 212℃
• Flash Point: 82℃
• Appearance: /
• Density: 1.27
• Vapor Pressure: 0.18mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,6-DIFLUORO-4-METHOXYBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIFLUORO-4-METHOXYBENZONITRILE(123843-66-3)
• EPA Substance Registry System: 2,6-DIFLUORO-4-METHOXYBENZONITRILE(123843-66-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• RIDADR: UN3439
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 123843-66-3(Hazardous Substances Data)

Usage

General Description

2,6-Difluoro-4-methoxybenzonitrile is a chemical compound with the molecular formula C8H5F2NO and a molar mass of 169.13 g/mol. It is a white solid that is sparingly soluble in water but dissolves well in organic solvents such as ethanol and diethyl ether. 2,6-Difluoro-4-methoxybenzonitrile is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Its unique chemical structure and properties make it a valuable building block for the production of various specialty chemicals. Additionally, 2,6-Difluoro-4-methoxybenzonitrile is known to be a versatile reagent in organic synthesis and can participate in a variety of chemical reactions, including nucleophilic substitutions and palladium-catalyzed cross-coupling reactions. Overall, this compound plays a crucial role in the development and production of important chemicals used in various industrial and research applications.

InChI:InChI=1/C8H5F2NO/c1-12-5-2-7(9)6(4-11)8(10)3-5/h2-3H,1H3

Upstream product

• 202865-61-0 1-bromo-2,6-difluoro4-methoxybenzene 
• 124-41-4 sodium methylate 
• 96606-37-0 2,4,6-trifluorobenzonitrile 
• 125369-56-4 2,6-difluoro-4-methoxybenzoyl chloride 
• 123843-65-2 2,6-difluoro-4-methoxybenzoic acid 
• 93343-10-3 3,5-difluoroanisol 
• 125369-57-5 2,6-difluoro-4-methoxybenzamide 

Downstream Products

• 123843-57-2 2,6-difluoro-4-hydroxybenzonitrile 
• 601516-55-6 2-fluoro-6-iodo-4-methoxy-benzonitrile 
• 601516-61-4 2-amino-6-iodo-4-methoxy-benzonitrile 
• 880885-37-0 2-amino-4-methoxy-6-pyrazol-1-yl-benzonitrile 
• 880885-42-7 2-amino-4-methoxy-6-thiazol-2-yl-benzonitrile 
• 880885-39-2 2-amino-4-methoxy-6-(3-methyl-pyrazol-1-yl)-benzonitrile 
• 880885-40-5 2-amino-4-methoxy-6-(2-methyl-2H-pyrazol-3-yl)-benzonitrile 
• 880885-38-1 2-amino-6-(4-chloro-pyrazol-1-yl)-4-methoxy-benzonitrile 
• 880885-41-6 2-amino-6-(2-ethoxymethyl-2H-pyrazol-3-yl)-4-methoxy-benzonitrile 
• 123843-69-6 4-cyano-3,5-difluorophenyl 4-pentylbenzoate 
• 123843-54-9 4-butoxy-2-fluorobenzoic acid 
• 123843-65-2 2,6-difluoro-4-methoxybenzoic acid 
• 944742-29-4 5-fluoro-7-methoxyquinazolin-4(3H)-one 

Relevant articles and documents

QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS

The present application relates to novel quinazoline compounds as inhibitors of type I receptor tyrosine kinases, the pharmaceutical compositions comprising one or more of the compounds and salts thereof as an active ingredient, and the use of the compounds and salts thereof in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals and especially in humans.

NOVEL COMPOUNDS

Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy.

The Synthesis and Transition Temperatures of Some Fluoro-Substituted 4-Cyanophenyl and 4-Cyanobiphenyl-4'-yl 4-Pentyl- and 4-Butoxy-Benzoates

A series of 4-cyanophenyl 4-X-benzoates and a series of 4-cyanobiphenyl-4'-yl 4-X-benzoates (X= pentyl, butoxy) have been prepared without fluoro-substitution and with mono-fluoro to tetra-fluoro-substitution; all possible combinations of substitution patterns at the positions ortho- to the cyano group and ortho- to the carboxylate group have been obtained in an attempt to determine the structural features which are responsible for some members of these series showing very large positive values of dielectric anisotropy.The synthesis of novel precursors required for the preparation of these esters is described and the melting points and transition temperatures of the esters are discussed and an explanation is provided for the variation of Tn-1 values with position and extent of fluoro-substitution. - Keywords: Fluoro-substitution, phenyl and biphenyl benzoates, terminal cyano namatogens.