123853-39-4

Basic information

• Product Name: 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid
• Synonyms: 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid;1,4-Dihydro-2,6-diMethyl-4-(2',3'-dichlorophenyl)-5-carboxy Meth;4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid monomethyl ester;3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-diMethyl-, 3-Methyl ester;Desethyl Felodipine;4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl ester;Monomethyl Felodipine;-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid
• CAS NO: 123853-39-4
• Molecular Formula: C₁₆H₁₅Cl₂NO₄
• Molecular Weight: 357.20854
• Mol File: 123853-39-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 483.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.375±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 1.65±0.70(Predicted)
• CAS DataBase Reference: 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid(123853-39-4)
• EPA Substance Registry System: 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid(123853-39-4)

Safety Data

• Hazardous Substances Data: 123853-39-4(Hazardous Substances Data)

Usage

Uses

Desethyl Felodipine is an impurity in the synthesis of Felodipine (F232375), a dihydropyridine calcium channel blocker.

Upstream product

• 110962-94-2 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate methyl ester-(2-cyanoethyl)ester 
• 105-45-3 acetoacetic acid methyl ester 
• 6334-18-5 2,3-dichlorobenzylaldehyde 
• 74073-22-6 (E/Z)-methyl 2-(2,3-dichlorobenzylidene)acetoacetate 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 14205-39-1 methyl 3-aminocrotonate 
• 74073-26-0 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate-(tert-butyl) methylester 
• 91189-59-2 4-(-2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl ester 
• 138279-25-1 4-(2,3-Dichloro-phenyl)-1-methoxymethyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2,2-dimethyl-propionyloxymethyl) ester 5-methyl ester 
• 138279-19-3 4-(2,3-Dichloro-phenyl)-1-methoxymethyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid mono-(2,2-dimethyl-propionyloxymethyl) ester 
• 141600-77-3 4-(2,3-Dichloro-phenyl)-1-methoxymethyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 
• 138279-28-4 (+)-methyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 

Downstream Products

• 127634-15-5 (R)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((R)-carboxy-phenyl-methyl) ester 5-methyl ester 
• 127634-16-6 (S)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((R)-carboxy-phenyl-methyl) ester 5-methyl ester 
• 166432-28-6 clevidipine 
• 133510-16-4 5-Chlorocarbonyl-4-(2,3-dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3-carboxylic acid methyl ester 

Relevant articles and documents

Preparation method of dihydropyridine compound (by machine translation)

Compared with the prior art, the method disclosed by the invention is suitable, for industrial production, II is, suitable for industrial production, is suitable for, industrial production, and is suitable for I. industrial production. (by machine transla

Novel synthesis method of clevidipine butyrate important intermediate

The invention discloses a preparation method of a clevidipine butyrate important intermediate. The preparation method comprises the steps that 3-Hydroxypropionitrile and diketene are condensed to obtain ethyl 2-cyanoacetoacetate (intermediate I); ethyl 2-cyanoacetoacetate, 2,3-dichlorobenzaldehyde and methyl 3-aminocrotonate are mixed, Hantzsch reaction is performed to obtain 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridine phthalate methyl ester-(2-cyano ethyl)-ester (intermediate II); the 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridine phthalate methyl ester-(2-cyano ethyl)-ester is hydrolyzed to obtain 4-(2,3- dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridine mono-Methyl phthalate, namely the clevidipine butyrate important intermediate. The intermediate involved in the synthesis process is not needed to be chromatographic separation and purification, the materials for synthesis are cheap and easy to obtain, the reaction speed is high, the conditions are mild, operation is simple and convenient, the process reliability is good, the yield is high, the purity of the obtained clevidipine butyrate important intermediate is above 99%, and the preparation method is suitable for mass production.

A high-purity butyric acid clevidipine preparation method (by machine translation)

The invention discloses a high-purity butyric acid clevidipine preparation method, is in 3-amino-crotonic acid cyanogen ethyl ester and 2,3- two chlorine Asia phenmethyl acetyl acetic acid methyl ester as the starting material, the cyclization, hydrolysis