1239016-36-4

Basic information

• Product Name: (R)-2-(2-chlorophenyl)propanoic acid
• Synonyms: (R)-2-(2-chlorophenyl)propanoic acid
• CAS NO: 1239016-36-4
• Molecular Weight: 184.622
• Mol File: 1239016-36-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-2-(2-chlorophenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(2-chlorophenyl)propanoic acid(1239016-36-4)
• EPA Substance Registry System: (R)-2-(2-chlorophenyl)propanoic acid(1239016-36-4)

Safety Data

• Hazardous Substances Data: 1239016-36-4(Hazardous Substances Data)

Upstream product

• 2184-85-2 2-(2-chloro-phenyl)-propanoic acid 
• 62784-66-1 bis(1-naphthyl)methanol 
• 2856-63-5 2-Chlorophenylacetonitrile 
• 64-18-6 formic acid 
• 873-31-4 2-chlorophenylacetylene 
• 201230-82-2 carbon monoxide 
• 2039-87-4 2-chlorostyrene 

Downstream Products

• 39959-67-6 (R)-α-(o-chlorophenyl)ethylamine 

Relevant articles and documents

Enantioselective Synthesis of Chiral Carboxylic Acids from Alkynes and Formic Acid by Nickel-Catalyzed Cascade Reactions: Facile Synthesis of Profens

We report a stereoselective conversion of terminal alkynes to α-chiral carboxylic acids using a nickel-catalyzed domino hydrocarboxylation-transfer hydrogenation reaction. A simple nickel/BenzP* catalyst displayed high activity in both steps of regioselective hydrocarboxylation of alkynes and subsequent asymmetric transfer hydrogenation. The reaction was successfully applied in enantioselective preparation of three nonsteroidal anti-inflammatory profens (>90 % ees) and the chiral fragment of AZD2716.

Simultaneous control of regioselectivity and enantioselectivity in the hydroxycarbonylation and methoxycarbonylation of vinyl arenes

Using a family of novel mononuclear and dinuclear palladium complexes of phanephos ligands, the simultaneous control of regioselectivity and enantioselectivity in the hydroxycarbonylation and alkoxycarbonylation of styrene derivatives has been realised for the first time. The Royal Society of Chemistry 2013.