1239462-77-1

Basic information

• Product Name: 5-bromo-7-(trifluoromethyl)quinoline
• Synonyms: 5-bromo-7-(trifluoromethyl)quinoline
• CAS NO: 1239462-77-1
• Molecular Formula: C10H5BrF3N
• Molecular Weight: 276.0526096
• Mol File: 1239462-77-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-bromo-7-(trifluoromethyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-7-(trifluoromethyl)quinoline(1239462-77-1)
• EPA Substance Registry System: 5-bromo-7-(trifluoromethyl)quinoline(1239462-77-1)

Safety Data

• Hazardous Substances Data: 1239462-77-1(Hazardous Substances Data)

Usage

General Description

5-bromo-7-(trifluoromethyl)quinoline is a chemical compound with the molecular formula C11H5BrF3N. It is a quinoline derivative with a bromine atom and a trifluoromethyl group attached to the quinoline ring. 5-bromo-7-(trifluoromethyl)quinoline is commonly used as a building block in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. Its unique structure and reactivity make it a valuable tool in the production of various functionalized quinoline derivatives. Additionally, 5-bromo-7-(trifluoromethyl)quinoline has potential biological activity and has been studied for its potential as an antiviral and antimicrobial agent. Overall, this compound is an important intermediate in chemical and pharmaceutical research, with potential applications in drug discovery and development.

Upstream product

• 56-81-5 glycerol 
• 54962-75-3 [3-bromo-5-(trifluoromethyl)phenyl]amine 
• 325-14-4 7‐(trifluoromethyl)quinoline 

Relevant articles and documents

5-bromo-7-trifluoromethyl quinoline synthetic method

The invention provides a 5-bromo-7-trifluoromethyl quinoline synthetic method. The 5-bromo-7-trifluoromethyl quinoline synthetic method comprises the following steps of by taking m-trifluoromethylaniline as a starting material, performing Skraup condensation to obtain 7-trifluoromethyl quinoline, and then performing reaction on the 7-trifluoromethyl quinoline and NBS to obtain 5-bromo-7-trifluoromethyl quinoline. According to the 5-bromo-7-trifluoromethyl quinoline synthetic method provided by the invention, a synthetic route of the method eliminates the disadvantages of incapability of purification, low yield and the like of a product in the existing synthetic technology, and the 5-bromo-7-trifluoromethyl quinoline synthetic method has the advantages of concision in synthetic route, reasonability in technology selection, low cost in raw materials, simpleness and availability in raw materials, convenience in operation and aftertreatment, high total yield and the like.

INHIBITORS OF JUN N-TERMINAL KINASE

The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula (I): or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.