1239576-12-5

Basic information

• Product Name: 4-chloro-3-(4-chloro-3-fluorophenyl)-N-((1R,3S)-3-hydroxycyclohexyl)isoxazole-5-carboxamide
• CAS NO: 1239576-12-5
• Molecular Weight: 373.211
• Mol File: 1239576-12-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-chloro-3-(4-chloro-3-fluorophenyl)-N-((1R,3S)-3-hydroxycyclohexyl)isoxazole-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-3-(4-chloro-3-fluorophenyl)-N-((1R,3S)-3-hydroxycyclohexyl)isoxazole-5-carboxamide(1239576-12-5)
• EPA Substance Registry System: 4-chloro-3-(4-chloro-3-fluorophenyl)-N-((1R,3S)-3-hydroxycyclohexyl)isoxazole-5-carboxamide(1239576-12-5)

Safety Data

• Hazardous Substances Data: 1239576-12-5(Hazardous Substances Data)

Upstream product

• 430534-91-1 4-chloro-3-fluorobenzoylchloride oxime 
• 202925-09-5 4-chloro-3-fluorobenzaldehyde oxime 
• 5527-95-7 4-chloro-3-fluorobenzaldehyde 
• 1239576-24-9 4-chloro-3-(4-chloro-3-fluorophenyl)isoxazole-5-carboxylic acid 
• 1110772-04-7 (1S,3R)-3-aminocyclohexan-1-ol 
• 1325228-74-7 C₁₀H₆Cl₂FNO₂ 
• 1325228-72-5 C₁₂H₈Cl₂FNO₃ 
• 1126636-64-3 C₁₀H₇ClFNO₂ 

Relevant articles and documents

Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles

Systematic optimisation of a poorly soluble lead series of isoxazole-3-carboxamides was conducted. Substitution of the 4-position with specific polar functionality afforded the requisite balance of potency, solubility and physicochemical properties. Compo