1239579-39-5Relevant articles and documents
Molecular modeling, total synthesis, and biological evaluations of c9-deoxy bryostatin 1
Keck, Gary E.,Poudel, Yam B.,Rudra, Arnab,Stephens, Jeffrey C.,Kedei, Noemi,Lewin, Nancy E.,Peach, Megan L.,Blumberg, Peter M.
supporting information; experimental part, p. 4580 - 4584 (2010/10/18)
(Chemical Equation Presented) 'OH' no you don't: The title compound 1 has been synthesized and evaluated for biological function. Molecular modeling of bryostatin 1 with the Cl domain of protein kinase C δ indicates that the C9OH of bryostatin 1 makes a hydrogenbonding contact to the protein. Despite the absence of the hydrogen-bonding contact for 1, it displays bryostatin-like biological effects in four assays using either U937 leukemia cells or prostate LNCaP cells.