1239605-11-8

Basic information

• Product Name: 2-ethynyl-4-(methyloxy)aniline
• Synonyms: 2-ethynyl-4-(methyloxy)aniline
• CAS NO: 1239605-11-8
• Molecular Weight: 147.177
• Mol File: 1239605-11-8.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2-ethynyl-4-(methyloxy)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethynyl-4-(methyloxy)aniline(1239605-11-8)
• EPA Substance Registry System: 2-ethynyl-4-(methyloxy)aniline(1239605-11-8)

Safety Data

• Hazardous Substances Data: 1239605-11-8(Hazardous Substances Data)

Upstream product

• 191348-14-8 2-iodo-4-methoxylaniline 
• 1066-54-2 trimethylsilylacetylene 
• 32338-02-6 2-bromo-4-methoxyaniline 
• 98447-30-4 2-bromo-4-methoxy-1-nitrobenzene 
• 591-20-8 3-Bromophenol 
• 5470-65-5 3-bromo-4-nitrophenol 

Downstream Products

• 1006-94-6 5-methoxylindole 
• 1440546-78-0 2-((2-acetamido-5-methoxyphenyl)ethynyl)-4-methoxy-N-methylbenzamide 
• 1440546-89-3 methyl 2-((2-acetamido-5-methoxyphenyl)ethynyl)-4-methoxybenzoate 
• 1440546-80-4 2-((2-Acetamido-5-methoxyphenyl)ethynyl)-4-methoxybenzoic acid 
• 1440546-79-1 methyl 2-((2-amino-5-methoxyphenyl)ethynyl)-4-methoxybenzoate 

Relevant articles and documents

Copper-Catalyzed Trifluoromethylation/Cyclization of Alkynes for Synthesis of Dioxodibenzothiazepines

A facile and efficient approach for the synthesis of the CF3-containing dioxodibenzothiazepines has been developed via copper-catalyzed trifluoromethylation/cyclization of alkynes utilizing a radical relay strategy. This method has demonstrated low cataly

Optimizing ligand structure for low-loading and fast catalysis for alkynyl-alcohol and-amine cyclization

A series of [Ru(Cp/Cp?)(PR2NR′2)(MeCN)]PF6 complexes were prepared, in which the steric and electronic properties of the primary coordination sphere were varied (R = Ph, t-Bu, Bn; and Cp vs. Cp?). These complexes were catalytically active in the cyclization of alkyne substrates with an intramolecular nucleophile (amine or alcohol) to produce 5-and 6-membered heterocycles. The effect of the 1° coordination sphere structure on catalyst performance was evaluated. Steric bulk around the metal centre was a key feature to achieve rapid catalysis at low temperatures. The catalyst [Ru(Cp)(Pt-Bu2NPh2)(MeCN)]PF6 gave a turnover number that was >1 order of magnitude more active than previous catalysts in the cyclization of the benchmark substrate 2-ethynylaniline. This catalyst is tolerant of a diversity of functional groups and is competent at the formation of various substituted indoles.

Synthesis of 2-(Trifluoromethyl)indoles via Domino Trifluoromethylation/Cyclization of 2-Alkynylanilines

A new method for the synthesis of 2-(trifluoromethyl)indoles using easily accessible 2-alkynylanilines and a well-established fluoroform-derived CuCF3 reagent is described. This method utilizes a domino trifluoromethylation/cyclization strategy