1240483-23-1Relevant articles and documents
PROCESS FOR THE PREPARATION OF PROSTAGLANDIN DERIVATIVES
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Page/Page column 9, (2012/02/01)
The invention concerns a new process for the preparation of prostaglandin derivatives, in particular prostaglandin F2α derivatives, for example bimatoprost, latanoprost and travoprost, the new intermediates of said process and their use in the preparation of prostagblandin derivatives.
PROCESS FOR THE PREPARATION OF PROSTAGLANDIN DERIVATIVES
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Page/Page column 21-22, (2010/09/17)
The invention concerns a new process for the preparation of prostaglandin derivatives, in particular prostaglandin F2α derivatives, for example bimatoprost, latanoprost and travoprost, the new intermediates of said process and their use in the preparation of prostaglandin derivatives.Said process comprises: a) reacting compounds of formula (I) with compounds of formula (II) to give compounds of formula (III) b) reducing with an asymmetric reducing agent the oxo group of the side chain of compounds of formula (III) to give compounds of formula (IV)