1240568-16-4

Basic information

• Product Name: 1-Cyclopropyl-4-nitro-1H-pyrazole
• Synonyms: 1-Cyclopropyl-4-nitro-1H-pyrazole;1H-Pyrazole, 1-cyclopropyl-4-nitro-
• CAS NO: 1240568-16-4
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.13868
• Mol File: 1240568-16-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 303.0±15.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.85±0.12(Predicted)
• CAS DataBase Reference: 1-Cyclopropyl-4-nitro-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclopropyl-4-nitro-1H-pyrazole(1240568-16-4)
• EPA Substance Registry System: 1-Cyclopropyl-4-nitro-1H-pyrazole(1240568-16-4)

Safety Data

• Hazardous Substances Data: 1240568-16-4(Hazardous Substances Data)

Usage

General Description

1-Cyclopropyl-4-nitro-1H-pyrazole is a chemical compound with the formula C6H6N4O2. It is a nitro derivative of pyrazole, a five-membered aromatic heterocyclic compound. 1-Cyclopropyl-4-nitro-1H-pyrazole is primarily used in the pharmaceutical industry as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its cyclopropyl group contributes to its unique reactivity and biological activity, making it a valuable intermediate in the production of complex organic molecules. Additionally, the nitro group can be utilized for further derivatization to modify the compound's properties. This chemical exhibits potential for further research and development in the field of medicinal chemistry and drug discovery.

Upstream product

• 2075-46-9 4-nitro-1H-pyrazole 
• 411235-57-9 cyclopropylboronic acid 

Downstream Products

• 1240567-18-3 1‐cyclopropyl‐1H‐pyrazol‐4‐amine 
• 1361941-15-2 5-tert-butyl-2-(3-(5-(1-cyclopropyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one 

Relevant articles and documents

FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF

The present disclosure relates to a class of fused pyrimidine compounds of Formula I, their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to a process of preparation of these fused pyrimidine compounds, and to pharmaceutical compositions containing them.

SULFONYLUREA DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I) and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

PYRROLO(PYRAZOLO)PYRIMIDINE DERIVATIVE AS LRRK2 INHIBITOR

The present invention relates to a pyrrolo(pyrazolo)pyrimidine derivative having efficacy as an LRRK2 inhibitor, a preparation method therefor, and a pharmaceutical composition for preventing or treating degenerative brain diseases, containing the same.